Basal cell carcinoma and squamous cell carcinoma are the most common cancers in the skin of the head and neck region where sun exposure is the most intense. The main principle of treatment is to remove the mass with clean surgical margins. In large masses, appropriate reconstruction of the large defect should be provided. Bilobe flaps can be used to close the defects in the malar region. In this case report, the clinical features of the disease, diagnostic approach, treatment modalities and reconstruction of the defect are reviewed in a case of squamous cell carcinoma arising from the skin of the head and neck.
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http://dx.doi.org/10.1007/s12070-024-05297-0 | DOI Listing |
Thorac Cancer
March 2025
Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, P. R. China.
Background: Robot-assisted thoracoscopic surgery (RATS) is more precise and flexible than video-assisted thoracoscopic surgery (VATS) for early-stage non-small cell lung cancer (NSCLC) treatment. This study compared the early postoperative functional recovery of patients who underwent triportal RATS with that of patients who underwent uniportal video-assisted thoracic surgery (UVATS) for segmentectomy.
Methods: This observational, prospective study included 172 patients with clinical stage I or II peripheral NSCLC who underwent RATS or UVATS segmentectomy.
Semin Diagn Pathol
March 2025
Department of Pathology, Baptist Hospital of Miami, Baptist Health System, Miami, FL, USA.
Non-invasive lobular neoplasia (LN) encompasses atypical lobular hyperplasia (ALH), classic lobular carcinoma in situ (CLCIS), florid lobular carcinoma in situ (FLCIS), and pleomorphic lobular carcinoma in situ (PLCIS). Lobular neoplasia is a neoplastic epithelial proliferation of the terminal duct lobular unit. A defining feature is discohesion due to the loss of E-cadherin, a protein that facilitates cell-to-cell adhesion.
View Article and Find Full Text PDFBull Cancer
March 2025
Dermatologie, CHU de Tours, Tours, France; Réseau CARADERM, France.
Merkel cell carcinoma (MCC) is a rare skin cancer that mainly affects the elderly, and whose incidence is increasing. Although the exact origin of this cancer remains uncertain, research in recent years has revealed that MCC develops through two oncogenesis pathways: virally induced by the Merkel polyomavirus (80% of cases) and induced by mutations linked to ultraviolet rays (20% of cases). MCC is an aggressive cancer, with a high mortality rate and limited therapeutic options in advanced stage.
View Article and Find Full Text PDFJ Am Acad Dermatol
March 2025
Fred Hutchinson Cancer Center, Seattle, WA; University of Washington, Seattle, WA. Electronic address:
Background: Merkel cell carcinoma (MCC) is an aggressive skin cancer with poor survival rates. Immune checkpoint inhibitors (ICIs) were FDA-approved for advanced MCC in 2017, but their real-world survival impact remains unclear.
Objective: Evaluate whether ICI introduction in the US corresponded with improved survival.
Cancer Lett
March 2025
Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China; Interdisciplinary Research Center of Frontier science and technology, Xi'an Jiaotong University, Xi'an, China. Electronic address:
Mitochondrial malfunction is traditionally viewed as a major factor in tumor growth and malignancy, while recent studies have introduced conflicting views suggesting the necessity of functional mitochondria for tumor growth. Despite these differing perspectives, the specific role of mitochondria in cutaneous squamous cell carcinoma (cSCC) remains poorly understood. In this study, we observed increased mitochondrial abundance and function during the development of cSCC.
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