Staphylococcal infection is as common as streptococcal infection as a cause of infection-related glomerulonephritis (IRGN). It is seen more frequently in the pediatric population and is relatively rare in adults. Glomerular disease manifests as either nephritic or nephrotic syndrome. A high index of suspicion is necessary for diagnosing this condition as it can be mistaken for other common conditions in the elderly. IRGN may present as volume overload and may masquerade as cardiorenal syndrome type 1 in patients with preexisting heart failure, emphasizing the importance of distinguishing between the two because the treatment and prognosis may be different. We present an older adult male who was evaluated for suspected acute decompensation of heart failure in the setting of recent left knee septic arthritis and was found to have IRGN. This diagnosis may be delayed or missed due to it mimicking similar conditions and it requires a high index of suspicion.
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http://dx.doi.org/10.7759/cureus.78753 | DOI Listing |
Europace
March 2025
Clinical Cardiac Academic Group, Genetic and Cardiovascular Sciences Institute, City-St George's University of London, London, UK.
Atrial fibrillation (AF) is one of the most common cardiac diseases and a complicating comorbidity for multiple associated diseases. Many clinical decisions regarding AF are currently based on the binary recognition of AF being present or absent with the categorical appraisal of AF as continued or intermittent. Assessment of AF in clinical trials is largely limited to the time to (first) detection of an AF episode.
View Article and Find Full Text PDFEur Heart J Acute Cardiovasc Care
March 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Background: Left ventricular (LV) ventricular-arterial coupling (VAC) refers to the ratio of afterload (effective arterial elastance) to contractility (end-systolic elastance) as an integrated marker of cardiac performance. We sought to determine whether the echocardiographic VAC ratio, defined using the ratio of LV end-systolic volume (LVESV) to stroke volume (SV), predicted mortality in the cardiac intensive care unit (CICU).
Methods: Mayo Clinic CICU patients from 2007 and 2018 were included.
JAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.
JAMA Cardiol
March 2025
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Importance: Food insecurity is associated with prevalent cardiovascular disease (CVD), but studies have been limited to cross-sectional data.
Objectives: To study whether food insecurity is associated with incident CVD and to determine whether this association varies by sex, education, or race.
Design, Setting, And Participants: This prospective cohort study was conducted among US adults without preexisting CVD participating in the CARDIA (Coronary Artery Risk Development in Young Adults) study from 2000 to August 31, 2020.
J Osteopath Med
March 2025
Medical Education at OhioHealth in Columbus, Columbus, OH, USA.
Context: Simulation-based medical education (SBME) is a method for enhancing learner skill prior to initiating care for real patients. Although the use of SBME continues to grow, there is limited data on simulations related to osteopathic medical training. Osteopathic manipulative medicine (OMM) applies hands-on techniques to facilitate healing.
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