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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893294 | PMC |
| http://dx.doi.org/10.1016/j.xkme.2025.100970 | DOI Listing |
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Using KeGFR for Vancomycin Dosing When Renal Clearance Is Acutely Changing: A Simulation Study in a Retrospective Cohort.
Kidney Med
April 2025
Department of Renal Medicine, Tan Tock Seng Hospital, Singapore.
Clinical applicability of urinary creatinine clearance for determining the initial dose of vancomycin in critically ill patients.
J Infect Chemother
February 2022
Department of Pharmacy, Hokkaido University Hospital, Kita 14-jo, Nishi 5-chome, Kita-ku, Sapporo, 060-8648, Japan. Electronic address:
Introduction: The purpose of this study was to evaluate the clinical applicability of urinary creatinine clearance (CrCl) for determining the initial dose of vancomycin (VCM) in critically ill patients and to assess VCM trough plasma concentration/maintenance daily dose (C/D) ratio in patients with augmented renal clearance (ARC).
Methods: As the primary outcome measure, correlations between estimated renal function and the VCM C/D ratio were compared using the following formulas: CrCl, Cockcroft-Gault equation (eCrCl) and KineticGFR equation (KeGFR). Patients were divided into those with or without changes in renal function.
Objective: To evaluate the predictability of serum vancomycin concentrations of critically ill patients using the new kinetic estimated glomerular filtration rate (KeGFR) and other three established eGFR formulae.
Materials And Methods: We calculated serum vancomycin concentrations using software provided by the manufacturer of vancomycin.
Results: Data were collected from 122 hospitalized adults.
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