Background: Asthma is associated with an increased risk of cardiovascular mortality, potentially influenced by dietary phosphorus intake through its effects on inflammation and oxidative stress.
Methods: Data from 7,539 asthma patients in the National Health and Nutrition Examination Survey (NHANES) 1999-2018 cohort were analyzed using weighted Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI). Kaplan-Meier survival curves and a nomogram were used to assess survival probabilities and individualized risk, while restricted cubic spline (RCS) analysis evaluated non-linear dose-response relationships. Sensitivity analyses were conducted to test the robustness of the findings.
Results: Higher dietary phosphorus intake was associated with reduced cardiovascular mortality (HR: 0.43; 95% CI: 0.22-0.85 for the highest vs. lowest quartile; for trend = 0.018). Kaplan-Meier curves showed improved survival with increasing phosphorus intake, a result consistently supported by subgroup analyses. RCS analysis confirmed a non-linear dose-response relationship, identifying a threshold at 1,861.52 mg/day, below which higher phosphorus intake was significantly associated with lower cardiovascular mortality. However, above this threshold, the protective effect diminished. Sensitivity analyses further validated these results.
Conclusion: Elevated dietary phosphorus intake is associated with reduced cardiovascular mortality in asthma patients, suggesting its potential as a dietary intervention.
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| http://dx.doi.org/10.3389/fnut.2025.1533514 | DOI Listing |
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