Background: Tardive dyskinesia (TD) is a movement disorder that is associated with the prolonged use of antipsychotics. The prevalence of TD varies widely from 20% to 50% but often undetected in schizophrenia patients treated with antipsychotics.
Aim: This study is aimed at investigating the prevalence of TD among schizophrenia patients treated with antipsychotics and identifying the associated factors. This study also investigates the association of TD with personal and social functioning performance, and the severity of illness.
Methods: This was a cross-sectional study conducted at a teaching hospital in Malaysia. Patients were assessed using the Abnormal Involuntary Movement Scale (AIMS), Personal and Social Performance Scale (PSP) and the Clinical Global Impression Scale (CGI).
Results: Seventy-eight patients were recruited in this study. The prevalence of TD was 35.9%. Older age (OR 4.079, p = 0.006), Chinese ethnicity (OR 4.486, p = 0.020), longer duration of schizophrenia and antipsychotic treatment (OR 5.312, p = 0.001 and OR 5.500, p = 0.002 respectively) were also significantly associated with TD. TD patients notably demonstrated severe impairments in the self-care domain (71.4%). The presence of TD is associated with more severe overall clinical impairment (53.6%).
Conclusion: TD remains a prevalent and concerning side effect of antipsychotic treatment in schizophrenia patients. There is a need for regular monitoring and the use of standardized assessment tools to detect TD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893478 | PMC |
| http://dx.doi.org/10.2147/NDT.S494458 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Connecting the dots: Understanding and addressing the metabolic impact of antipsychotic and antidepressant medications.
Ann N Y Acad Sci
March 2025
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.
Serious mental disorders such as schizophrenia and major depression are associated with considerable morbidity and mortality, resulting in much shorter life expectancies in those affected. The discovery of antipsychotic medications ushered in improved health outcomes for people with serious mental disorders but also brought about increased morbidity due to their metabolic side effects, including obesity and diabetes mellitus. Antidepressant medications have a more favorable metabolic side effect profile, but some can still cause weight gain and hyperglycemia.
View Article and Find Full Text PDFUsing normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data.
Elife
March 2025
Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic.
Longitudinal neuroimaging studies offer valuable insight into brain development, ageing, and disease progression over time. However, prevailing analytical approaches rooted in our understanding of population variation are primarily tailored for cross-sectional studies. To fully leverage the potential of longitudinal neuroimaging, we need methodologies that account for the complex interplay between population variation and individual dynamics.
View Article and Find Full Text PDFVirtual reality as a novel therapeutic tool in psychiatry: will virtual reality intervention for families rescue hikikomori?
Curr Opin Psychiatry
February 2025
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University.
Purpose Of Review: Digital technology is beginning to revolutionize psychiatry. Virtual reality (VR) allows users to experience a virtual space through their three primary senses. In psychiatry, social skills training (SST), including role-play, has been introduced in occupational therapy to improve patients' social abilities.
View Article and Find Full Text PDFPurpose Of Review: This review examines the literature associating cannabis with schizophrenia, glutamate dysregulation in schizophrenia, and cannabis involvement in glutamate pathways. Cannabis use is widespread among adolescents world-wide and is sold legally in many countries for recreational use in a variety of forms. Most people use it without lasting effects, but a portion of individuals have negative reactions that manifest in acute psychotic symptoms, and in some, symptoms continue even after the use of cannabis has ceased.
View Article and Find Full Text PDFPsychosocial Interventions in the Rehabilitation and the Management of Psychosis and Schizophrenia: A Systematic Review on Digitally-Delivered Interventions.
Actas Esp Psiquiatr
March 2025
Unit of Clinical Psychiatry, Department of Clinical Neurosciences/DIMSC, Polytechnic University of Marche, 60126 Ancona, Italy.
Background: Schizophrenia and psychotic disorders are disabling, complex and severe psychiatric conditions, which may pose a significant therapeutic challenge. Integrating current psychopharmacological treatment with psychosocial interventions demonstrated a higher efficacy in terms of prognosis. However, most schizophrenia or psychotic patients may have restricted or no access to evidence-based psychosocial interventions, mainly due to poor dissemination of specialized interventions or stigma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!