Introduction: Myricariae Ramulus (MR) is a traditional anti-inflammatory Tibetan medicine derived from the branches and leafy twigs of various Myricaria plants, such as Myricaria wardii Marquand.
Objective: This study performed spectrum-effect analyses on 15 batches of MR, sourced from various origins and medicinal parts, to identify quality markers associated with its anti-inflammatory effects.
Materials And Methods: The anti-inflammatory effects of different extracts and fractions from M. wardii were evaluated in lipopolysaccharide-infected mice. Further analysis was conducted utilizing UPLC-Q-TOF-MS/MS in the negative ion mode to recognize the compound composition of ethyl acetate (EA) fractions from the branches and leafy twigs of M. wardii. Subsequently, anti-complementary and antioxidant activities were conducted via the hemolysis and ABTS radical scavenging methods, and UPLC chromatograms for 15 batches of samples were established. Finally, spectrum-effect analysis was performed by gray relational analysis and partial least squares regression to identify the quality markers.
Results: The EA fraction effectively alleviated inflammatory responses by regulating IL-6 and myeloperoxidase. A total of 46 compounds from M. wardii were recognized, which mainly encompass gallic derivatives, phenolic amides, flavonoids, and terpenoids. Activity assays demonstrated that the two activities of leafy twigs were significantly stronger than those of branches. Moreover, an obvious distinction in chemical composition between the two parts was observed. Combining the spectrum-effect analysis results, methyl 3,4-dihydroxy-5-methoxybenzoate, myricarin A, protocatechualdehyde, and N-feruloyl normetanephrine from the branches, and protocatechuic acid from the leafy twigs were considered quality markers.
Conclusion: These results provide insights into improving the quality control of MR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pca.3527 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chemical Recognition and Spectrum-Effect Relationship of UPLC-MS Chromatograms With Anti-Complementary and Antioxidant Activities of Myricariae Ramulus.
Phytochem Anal
March 2025
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, China.
Introduction: Myricariae Ramulus (MR) is a traditional anti-inflammatory Tibetan medicine derived from the branches and leafy twigs of various Myricaria plants, such as Myricaria wardii Marquand.
Objective: This study performed spectrum-effect analyses on 15 batches of MR, sourced from various origins and medicinal parts, to identify quality markers associated with its anti-inflammatory effects.
Materials And Methods: The anti-inflammatory effects of different extracts and fractions from M.
Extinction Risk Assessment and Chemical Composition of Aerial Parts Essential Oils from Two Endangered Endemic Malagasy Species.
Plants (Basel)
May 2023
Département Phytochimie et Contrôle Qualité, Institut Malgache de Recherches Appliquées (IMRA), Antananarivo 102, Madagascar.
Seven essential oil samples of two endemic species of Malagasy sage, Baker and Baker, were investigated via GC(RI), GC-MS and C NMR spectrometry. In total, 81compounds were identified accounting for 93.5% to 98.
View Article and Find Full Text PDFFrom the Wild to the Field: Documentation, Propagation, Pilot Cultivation, Fertilization, and Phytochemical Evaluation of the Neglected and Underutilized Medik. (Rosaceae).
Plants (Basel)
March 2023
Institute of Plant Breeding and Genetic Resources, Hellenic Agricultural Organization Demeter, 57001 Thessaloniki, Greece.
The snowy Mespilus, or serviceberry ( Medik., Rosaceae) represents a neglected and underutilized small fruit tree species with high nutritional value. In this work, we present the results of a long-term study facilitating the sustainable exploitation of as a new germplasm resource from the Greek flora.
View Article and Find Full Text PDFAn investigation of browsing enrichment, especially non-leaf foraging, on giraffes (Giraffa camelopardalis reticulata) at Kyoto City Zoo in Japan.
Zoo Biol
January 2023
School of veterinary medicine, Azabu University, Sagamihara, Kanagawa, Japan.
Browsing enrichment may aid in developing species-specific behaviors for giraffes managed in zoos as a means of improving animal welfare. By nature, giraffes are tree-feeding animals, including tree bark, but the extent of food other than leaves as a form of browsing enrichment has not been well investigated. Therefore, to investigate the effectiveness of non-leaf foraging, three giraffes at the Kyoto City Zoo in Japan were observed for 228 h from May 2019 to February 2020.
View Article and Find Full Text PDFPaleohistology of the Cretaceous resin-producing conifer Geinitzia reichenbachii using X-ray synchrotron microtomography.
Am J Bot
September 2021
CNRS UMR 6118 Géosciences, Université Rennes 1, Campus de Beaulieu, 263 avenue du Général Leclerc, Rennes, `Cedex, 35042, France.
Article Synopsis
- The conifer Geinitzia reichenbachii was prevalent during the Cretaceous period in Laurasian floras, but detailed studies on its structure and ecology were lacking until now.
- New research utilizing advanced imaging techniques has revealed the three-dimensional preservation of its leaf structures, including various tissues and resin ducts, providing insights into its biology.
- The findings suggest that G. reichenbachii thrived in coastal environments with challenging conditions, indicating its potential contribution to amber production in western France during the Cretaceous.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!