Over the last few years, numerous hospitals in France have been subject to increasingly frequent and severe cyberattacks that have disrupted healthcare provision to varying degrees. To mitigate this threat, especially in light of the forthcoming 2024 Olympic Games, Assistance Publique-Hôpitaux de Paris in Paris has been developing contingency plans that have been tested in simulated exercises called CRYPTolocker EXercice since May 2021. The latest simulated ransomware cyberattack that involved more than 200 participants took place on July 5, 2023, and lasted for 24 hours. Although cybersecurity contingency plans are confidential for obvious reasons, this article presents the multidisciplinary organization of the simulated attack based on previous experiences from other hospitals and general findings that are in the public domain. It was found that the procedures in place worked well overall, and countermeasures were quickly implemented to limit the severity of this simulated cyberattack. However, failings were observed in intra- and extra-hospital communication, and conflicting priorities between different categories of personnel (administrative, managerial, and clinical) hampered the information technology team in resolving various issues. Furthermore, it was found that mental fatigue, task saturation, and information overload may have overwhelmed senior managers at sporadic intervals. This often resulted in an action-reaction approach being used to find temporary solutions to immediate problems. Consequently, senior managers who participated in this simulated cyberattack were unable to think strategically and anticipate demands for middle- and long-term issues. This unprecedented exercise was an important learning experience for all participants, and the lessons learned will help further improve contingency planning and cyber resilience. It advised that all hospitals worldwide adopt and develop a similar multidisciplinary approach (taking into account their local contexts) to limit the deleterious effects of a potential cyberattack that undoubtedly will become more prevalent in the future.
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http://dx.doi.org/10.5055/jem.0885 | DOI Listing |
ACS Synth Biol
March 2025
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Cell-free synthetic biology biosensors have potential as effective diagnostic technologies for the detection of chemical compounds, such as toxins and human health biomarkers. They have several advantages over conventional laboratory-based diagnostic approaches, including the ability to be assembled, freeze-dried, distributed, and then used at the point of need. This makes them an attractive platform for cheap and rapid chemical detection across the globe.
View Article and Find Full Text PDFJ Speech Lang Hear Res
March 2025
Department of Speech, Language, and Hearing Sciences, The University of Arizona, Tucson.
Purpose: The goal of this study was to examine potential mediators of the relationship between developmental language disorder (DLD) status and executive function performance.
Method: Participants included preschoolers, of whom 80 met the diagnostic criteria for DLD and 103 were categorized as having typical language abilities. Participants' nonverbal IQ and receptive vocabulary were assessed via standardized tests, and their executive function was tested using the Dimensional Change Card Sort.
ACS Sens
March 2025
Centre for Innovative Materials for Health, School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
Herein, a novel and simple electrospray (ES) printing technique was developed for the fabrication of ultrathin graphene layers with precisely controlled nanometer-scale thickness, where graphene oxide (GO) was electrosprayed on wafers and subsequently chemically reduced into reduced GO (rGO). Utilizing that technique, we prepared ultrathin rGO in-plane graphene field-effect transistor (GFET)-based biosensors coupled with a portable prototype measuring system for point-of-care detection of pathogens. We illustrate the use of such prepared GFETs to detect COVID-19, using the SARS-CoV-2 nucleocapsid protein antigen (N-protein) and genomic viral RNA as detection targets.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.
Phosphorus is considered an ideal anode material for lithium ion storage by virtue of its high theoretical capacity and moderate lithiation potential. However, issues such as large volume expansion of phosphorus leading to an electrical loss of contact and instability of the solid electrolyte interface hinder its practical performance. Improvement strategies that can effectively suppress volume expansion and provide stable electrical contacts are urgently needed.
View Article and Find Full Text PDFJ Am Chem Soc
March 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstrasse 28/30, Münster D-48149, Germany.
Lithium argyrodites LiPS ( = Cl, Br, I) are a promising class of solid-state electrolytes with the potential to achieve high conductivities (>10 mS·cm) necessary for use in solid-state batteries. Previous research has shown that structural factors, in particular, site disorder between the sulfide and halide anions, can impact the ionic conductivity of lithium argyrodites. One current hypothesis for this correlation between anion site disorder and ionic transport is a connection to the lithium-ion substructure.
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