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http://dx.doi.org/10.4103/mgr.MEDGASRES-D-24-00103 | DOI Listing |
Med Gas Res
June 2025
Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
J Colloid Interface Sci
March 2025
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon 999077, Hong Kong, China; Joint Research Center in Biosensing and Precision Theranostics, The Hong Kong Polytechnic University, Kowloon 999077, Hong Kong, China; Hong Kong Polytechnic Shenzhen Research Institute, Shenzhen 518057, China. Electronic address:
The tumor microenvironment (TME) exhibits a specific feature of hypoxia, which poses significant challenges for oxygen (O)-dependent treatments. In this study, we developed an intelligent nanoplatform (PEGylated AIPH@MSN/CDs-MnO, denoted as A@M/C-Mn) by integrating a photosensitizer of red carbon dots (CDs) with a thermolabile initiator-loaded mesoporous silica nanoparticle (AIPH@MSN, denoted as A@M), and then growing manganese dioxide nanosheets (MnO NS) in situ and PEGylating the structure to achieve TME-responsive synergistic diagnosis and phototherapy against hypoxic tumors. The outer-layer MnO NS has the capability to decompose endogenous hydrogen peroxide (HO) in the acidic TME, thereby producing O to alleviate hypoxia while releasing Mn.
View Article and Find Full Text PDFJ Nanobiotechnology
March 2025
School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Microbial keratitis, a sight-threatening corneal infection, remains a significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occurrence of drug resistance, with poor prognosis. Novel treatment techniques, with their unique properties and targeted delivery capabilities, offers a promising solution to overcome these challenges.
View Article and Find Full Text PDFAdv Sci (Weinh)
March 2025
Research Center of Nanomedicine Technology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, P. R. China.
Near-infrared (NIR) activated photosensitizers based on heavy-atom-free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR-activated heavy-atom-free photosensitizer (named Cy-BF) is developed. Cy-BF is then encapsulated with phospholipids and platelet exosome vesicles to create platelet exosomes vesicles biomimetic and Cy-BF loaded hybrid liposomes (named CHL) Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation-induced broadening of absorption spectra and NIR (760 nm laser) activates photothermal therapy and type I photodynamic therapy.
View Article and Find Full Text PDFLasers Med Sci
March 2025
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.
Stress urinary incontinence (SUI) significantly impacts the quality of life, necessitating innovative treatment options beyond conventional approaches. This comprehensive review aimed to evaluate laser therapy as a promising intervention for SUI management. A systematic search was conducted using the keywords "laser" and "stress urinary incontinence" in the PubMed, Scopus, Web of Science, and Embase databases.
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