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Piezocatalysis for gas generation and disease therapy.
Med Gas Res
June 2025
Beijing Key Laboratory of Micro-Nano Energy and Sensor, Center for High-Entropy Energy and Systems, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, China (Zhao Q, Zhong S, Li L).
Ultrasound-Induced Piezocatalysis Triggered NO Generation for Enhanced Hypoxic Tumor Therapy.
ACS Appl Mater Interfaces
March 2023
Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China.
Conventional NO gas generation based on l-arginine (l-Arg) is usually dependent on HO and O, both of which are very limited within the tumor microenvironment, thus greatly limiting l-Arg's therapeutic effect. Herein, a novel nanoplatform for efficiently triggering NO production based on ultrasound-induced piezocatalysis was developed, which was fabricated by coating amphiphilic poly-l-arginine (DSPE-PEG-Arg, DPA) on the piezoelectric material of barium titanate (BTO). The resulting BTO@DPA nanoparticles can efficiently generate HO, O, and O via ultrasound-induced piezocatalysis based on BTO and oxidize the surface arginine to produce NO, which can even further interact with the reactive oxygen species (ROS) to produce more reactive peroxynitrite, thus inducing serious tumor cell apoptosis both in hypoxia and normoxia.
View Article and Find Full Text PDFUltrasound-Triggered Piezocatalysis for Selectively Controlled NO Gas and Chemodrug Release to Enhance Drug Penetration in Pancreatic Cancer.
ACS Nano
February 2023
Department of Ultrasound, Peking University Third Hospital, Beijing 100191, China.
Nitric oxide (NO) is drawing widespread attention in treating pancreatic ductal adenocarcinoma (PDAC) as a safe and therapeutically efficient technique through modulating the dense fibrotic stroma in the tumor microenvironment to enhance drug penetration. Considerable NO nanogenerators and NO releasing molecules have been developed to shield the systemic toxicity caused by free diffusion of NO gas. However, on-demand controlled release of NO and chemotherapy drugs at tumor sites remains a problem limited by the complex and dynamic tumor microenvironment.
View Article and Find Full Text PDFDemonstration of Enhanced Piezo-Catalysis for Hydrogen Generation and Water Treatment at the Ferroelectric Curie Temperature.
iScience
May 2020
Department of Mechanical Engineering, University of Bath, Bath BA2 7AY, UK. Electronic address:
Hydrogen can contribute significantly to the energy mix of the near future, as it is an attractive replacement for fossil fuels due to its high energy density and low greenhouse gas emission. A fascinating approach is to use the polarization change of a ferroelectric due to an applied stress or temperature change to achieve piezo- or pyro-catalysis for both H generation and wastewater treatment. We exploit low Curie temperature (T) ferroelectrics for polarization-driven electrochemical reactions, where the large changes in polarization and high activity of a ferroelectric near its T provides a novel avenue for such materials.
View Article and Find Full Text PDFA Floatable Piezo-Photocatalytic Platform Based on Semi-Embedded ZnO Nanowire Array for High-Performance Water Decontamination.
Nanomicro Lett
January 2019
Department of Mechanical Engineering, Michigan State University, 428 S. Shaw Lane, East Lansing, MI, 48823, USA.
ZnO nanowires were securely immobilized onto a floatable photocatalytic platform, which had a uniform diameter (55 ± 5 nm) and length (1.5 ± 0.3 μm).
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