The whole plant of Thunb., called Shu Yangquan in traditional Chinese medicine, has the traditional function of clearing away heat and toxic material. Chemical investigation on the ethanol extract of afforded a new lignanamide () and a known compound caffeic acid ethyl ester (). Compound displayed moderate antineuroinflammatory effects (IC values of 25.3 μM) compared with minocycline (IC value of 12.1 μM) against NO production on LPS-treated BV2 cells.
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One neuroprotective lignanamide from Solanum Septemlobum Thunb.
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Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.
The whole plant of Thunb., called Shu Yangquan in traditional Chinese medicine, has the traditional function of clearing away heat and toxic material. Chemical investigation on the ethanol extract of afforded a new lignanamide () and a known compound caffeic acid ethyl ester ().
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Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Laboratory of Quality and Safety Risk Assessment on Agro-products Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Agro-products Quality and Safety Control in Storage and Transport Process, Beijing, China; Western Agricultural Research Center, Chinese Academy of Agricultural Sciences, Changji 831100, China. Electronic address:
Lignanamides are a class of compounds containing amide functional groups in lignans. These compounds have excellent anti-inflammatory and neuroprotective, which have shown great potential in terms of food additives, medicine and health supplement. We summarized the recent progress of lignanamides, including chemical constituents, extraction methods, biological activities, and synthetic pathways.
View Article and Find Full Text PDFExploring the neuroprotective activity of a lignanamides-rich extract in human neuroblastoma SH-SY5Y cells under dimethyl sulfoxide-induced stress.
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Dipartimento Di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Università Della Campania "Luigi Vanvitelli", Caserta, Italy.
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