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Highlights from the plenary session: clinically relevant outcomes.
Rheumatology (Oxford)
March 2025
Vasculitis Unit of Vienna, Vienna, Austria.
The plenary session on clinically relevant outcomes in systemic vasculitis emphasized the significance of monitoring creatinine, haematuria and proteinuria for predicting renal outcomes, recovery of kidney function in severe ANCA glomerulonephritis and outcomes post-kidney transplantation in anti-glomerular basement membrane disease. These findings have the potential to enhance clinical practice by refining prognostication and treatment strategies. Future research gaps include exploring the predictive role of proteinuria and understanding the impact of different clinical phenotypes on disease outcomes in Takayasu arteritis.
View Article and Find Full Text PDFUnderstanding frailty screening of older adults in the emergency department: A survey of emergency physicians in Ontario.
Acad Emerg Med
March 2025
Division of Emergency Medicine, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Association between physical activity and frailty transitions in middle-aged and older adults: a nationwide longitudinal study.
Int J Behav Nutr Phys Act
March 2025
School of Public Health, Wenzhou Medical University, Wenzhou, China.
Background: Frailty has become an important health problem in the middle-aged and older people population. Physical activity (PA) is a key intervention for frailty prevention and management. However, studies of the association between COVID-19 pre-pandemic PA and the worsening or improvement of frailty during the pandemic remain unclear.
View Article and Find Full Text PDFA systematic review of assessment tools for cognitive frailty: Use, psychometric properties, and clinical utility.
J Frailty Aging
March 2025
Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, 5001, South Australia, Australia. Electronic address:
Background: The concept of 'cognitive frailty' (CF) was first developed by an international consensus group in 2013 and defined as evidence of both physical frailty and cognitive impairment without a clinical diagnosis of AD or another dementia. CF has been associated with adverse health outcomes and early identification is vital. Difficulty in the assessment of CF however is the lack of a diagnostic gold standard.
View Article and Find Full Text PDFThe effects of major abdominal surgery on skeletal muscle mitochondrial respiration in relation to systemic redox status and cardiopulmonary fitness.
Exp Biol Med (Maywood)
March 2025
Peninsula Medical School, Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, United Kingdom.
More complex surgeries are being performed in increasingly sicker patients, resulting in a greater burden of postoperative morbidity. Delineating the metabolic and bioenergetic changes that occur in response to surgical stress may further our understanding about how humans respond to injury and aid the identification of resilient and frail phenotypes. Skeletal muscle biopsies were taken from patients undergoing hepato-pancreatico-biliary surgery at the beginning and end of the procedure to measure mitochondrial respiration and thiol status.
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