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The Power of Prions: The Strange and Essential Proteins That Can Cause Alzheimer's, Parkinson's, and Other Diseases.
Cogn Behav Neurol
March 2025
Department of Neurology, Vanderbilt Medical Center North, Vanderbilt University, Nashville, Tennessee.
A nested cross validation approach to machine learning model performance evaluation on a small dataset for Creutzfeldt-Jakob disease diagnosis.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
The use of machine learning (ML) to diagnose neurological diseases has become increasingly popular. However, some rare neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) suffer from the way that the traditional diagnosis relying abnormal protease-resistant prion protein accumulation in post-mortem brain tissue as the definitive confirmation of the disease such that the possibility of early detection and intervention is very limited. One recent ML study has shown promise in aiding the identification of CJD with greater accuracy and efficiency using protein levels in cerebrospinal fluid that could be obtained in-vivo.
View Article and Find Full Text PDFA fatal familial insomnia patient initially misdiagnosed as Alzheimer's disease: a case report.
BMC Neurol
December 2024
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu, 210029, China.
Background: Fatal familial insomnia (FFI) is a rare autosomal dominant inherited disease and a type of prion diseases. We report a case of fatal familial insomnia (FFI) in a 52-year-old man who was initially misdiagnosed as Alzheimer's disease.
Case Presentation: The patient presented with persistent insomnia as the initial symptom, accompanied by cognitive impairment, autonomic dysfunction, and disorders of voluntary movement.
Computing edge version of metric dimension of certain chemical networks.
Sci Rep
May 2024
Faculty of Transport and Aviation Engineering, Silesian University of Technology, Katowice, Poland.
In the modern digital sphere, graph theory is a significant field of research that has a great deal of significance. It finds widespread application in computer science, robotic directions, and chemistry. Additionally, graph theory is used in robot network localization, computer network problems and the formation of various chemical structures for networks.
View Article and Find Full Text PDFThe Single Toxin Origin of Alzheimer's Disease and Other Neurodegenerative Disorders Enables Targeted Approach to Treatment and Prevention.
Int J Mol Sci
February 2024
Alzheon, Inc., Framingham, MA 01701, USA.
Article Synopsis
- New research indicates that the aggregation of misfolded proteins is a key factor in the development of Alzheimer's disease (AD) and similar neurodegenerative disorders, leading to a new theory of brain degeneration.
- Genetic evidence highlights soluble beta-amyloid aggregates as the main neurotoxin responsible for the onset and progression of AD, rather than the larger, less reactive amyloid plaques.
- Understanding the harmful effects of these soluble aggregates (oligomers and protofibrils) is crucial for developing effective treatments that can address the root causes of neurodegeneration in AD and other related diseases.
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