Introduction: This study explores the presence and clinical significance of Epstein- Barr Virus (EBV) and Human Papillomavirus (HPV) in papillary thyroid carcinoma (PTC). EBV and HPV are known to contribute to various cancers, but their roles in thyroid cancer development are debated.
Method: Paraffin-embedded tissue blocks from PTC patients (n=255) who underwent thyroid surgery between 2020 and 2021 were analyzed for EBV and HPV DNA using PCR-based methods.
Results: Results showed EBV positivity in 45.1% of PTC cases, significantly higher than in benign thyroid tumors (35.2%), while HPV positivity was low (0.7%). EBV positivity was not associated with age, gender, lesion type, lymph node metastasis, or extrathyroidal extension but was significantly higher in PTC cases with concurrent Hashimoto's thyroiditis. The study suggests a notable presence of EBV in PTC, especially in cases with Hashimoto's thyroiditis, but indicates a limited role for HPV in thyroid cancer.
Conclusion: Further research is warranted to understand the specific pathogenic mechanisms and potential therapeutic implications of EBV and HPV in thyroid cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0118715303355722250127061453 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A novel dominant-negative variant of IRF8 in a mother and son: Clinical, phenotypic and biological characteristics.
J Allergy Clin Immunol
March 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn. Electronic address:
Background: The few reported patients with pathogenic IRF8 variants have manifested 2 distinct phenotypes: (1) an autosomal recessive severe immunodeficiency with significant neutrophilia and absence of or significant decrease in monocytes and dendritic cells and (2) a dominant-negative form with only a decrease in conventional type 2 dendritic cells (cDC2s) and susceptibility to mycobacterial disease.
Objectives: Genetic testing of a child with persistent EBV viremia identified a novel IRF8 variant: c.1279dupT (p.
Epstein-Barr Virus and Human Papillomavirus Infection in Papillary Thyroid Carcinoma: A Correlation Study.
Endocr Metab Immune Disord Drug Targets
March 2025
Department of Otolaryngology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Introduction: This study explores the presence and clinical significance of Epstein- Barr Virus (EBV) and Human Papillomavirus (HPV) in papillary thyroid carcinoma (PTC). EBV and HPV are known to contribute to various cancers, but their roles in thyroid cancer development are debated.
Method: Paraffin-embedded tissue blocks from PTC patients (n=255) who underwent thyroid surgery between 2020 and 2021 were analyzed for EBV and HPV DNA using PCR-based methods.
Analysis of HPV-16 viral load, integration status, and p16 expression in relation to EBV co-infection and cervical lesion severity.
Sci Rep
March 2025
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.
Cervical cancer, one of the most common cancers in women, is primarily driven by high-risk human papillomaviruses (HPV) infections, particularly HPV-16. Co-infection with Epstein-Barr virus (EBV) has been reported to exacerbate disease progression by influencing HPV genome integration. This study examines HPV-16 integration status, p16INK4a expression, and their relationship with EBV co-infection and viral load in cervical cancer cases.
View Article and Find Full Text PDFDecoding the molecular complexity of viruses in human cancer: insights into host cell infection, oncogenesis, and therapeutic prospects.
Crit Rev Microbiol
March 2025
Cancer Biology Division, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Infections account for approximately 15% of human cancers worldwide. Viruses are the most predominant infectious agents and can infect and alter various types of human cells thereby leading to the development of various forms of cancer. Current studies have reported that Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HBC), human papillomavirus (HPV), Kaposi's sarcoma-associated herpesvirus (KSHV), human T-lymphotropic virus 1 (HTLV-1), Markel cell polyomavirus (MCPyV), and BK polyomavirus are the most important oncogenic viruses that are directly involved in the initiation and progression of cancer.
View Article and Find Full Text PDFVaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers.
J Clin Med
February 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
Viral infections such as human papillomavirus (HPV) and Epstein-Barr virus (EBV) play a critical role in the onset of oropharyngeal (OPC) and nasopharyngeal cancer (NPC), respectively. Despite advancements in targeted therapies and immunotherapies, in the recurrent/metastatic setting, these tumors remain incurable diseases with poor prognosis. The development of therapeutic tumor vaccines, utilizing either neoantigens or oncoviral antigens, represents a promising addition to the cancer immunotherapy arsenal.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!