Objective: We aimed to evaluate the efficacy of routine post-op X-ray in cochlear implantation patients.
Study Design: Retrospective chart review study.
Setting: Primary or revision cochlear implant patients who had routine postoperative X-ray (XR) or had planned postoperative computed tomography (CT) due to clinical concerns for array malposition.
Methods: All images were reviewed, and those were considered abnormal if there was a bent tip, kinking, incomplete insertion, or if the electrode array didn't follow the expected cochlear curvature. Postoperative CT scans were performed in patients with abnormal postoperation X-ray, or if there were abnormal surgical findings encountered during insertion which raised the suspicion for suboptimal placement.
Results: A total of 195 patients with a mean age of 64.8 ± 18.9 years were included. XRs were performed in 188 patients and others had CT scan from the beginning. Only 2 out of 188 patients had abnormal findings on XR, which showed malposition of the electrode in one patient and a tip fold over and incomplete insertion in the other one. Both patients with abnormal findings had labyrinthitis ossificans. The patient with tip fold over ultimately underwent re-implantation. Another patient with incomplete insertion had required extended basal turn drilling during implantation, and no additional measures were taken.
Conclusion: Routine XR findings did not provide the reason for additional intervention, and its benefit for patients without demonstrable cochlear abnormalities was minimal. Post-op XR can be informative in selected high risk patients, but CT imaging is a reasonable alternative to better define anatomic array location in patients particularly at risk.
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http://dx.doi.org/10.1002/ohn.1144 | DOI Listing |
Otolaryngol Head Neck Surg
March 2025
Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, USA.
Objective: We aimed to evaluate the efficacy of routine post-op X-ray in cochlear implantation patients.
Study Design: Retrospective chart review study.
Setting: Primary or revision cochlear implant patients who had routine postoperative X-ray (XR) or had planned postoperative computed tomography (CT) due to clinical concerns for array malposition.
Gut Liver
March 2025
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Pyloric dysfunction is defined as hypertonia or spasm of the pyloric sphincter. The pylorus plays a key role in gastric emptying, but its function remains incompletely understood. Most studies have focused on gastroparesis regardless of the underlying pathophysiology.
View Article and Find Full Text PDFTransl Med Aging
February 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
LINE-1 (L1) and Alu are two families of transposable elements (TEs) occupying ~17% and ~11% of the human genome, respectively. Though only a small fraction of L1 copies is able to produce the machinery to mobilize autonomously, Alu and degenerate L1s can hijack their functional machinery and mobilize . The expression and subsequent mobilization of L1 and Alu can exert pathological effects on their hosts.
View Article and Find Full Text PDFAdv Sci (Weinh)
March 2025
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Prime editors (PEs) have emerged as transformative tools for precision genome engineering, yet their broader application remains constrained by incomplete understanding of repair mechanisms. In this study, it is found that an increase in the methylation level of the CpG sequence on the newly generated strand can increase PE efficiency and that de novo DNA methyltransferases (DNMT3A/3B) are involved in the PE repair pathway. On the basis of these novel findings, the development of an episomal element-driven PE system (epiPE) achieved through the use of EBNA1/oriP are presented, which increases methylation levels around target sites and prolongs PE expression.
View Article and Find Full Text PDFBMC Vet Res
March 2025
Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Background: Intervertebral disc disease (IVDD) is a major welfare issue in chondrodystrophic dogs. It is a consequence of chondroid metaplasia of the nucleus pulposus, leading to premature degeneration and calcification of the intervertebral discs (IVDs). Radiographic grading based on the number of calcified discs visible on radiograph (CDVR) between the ages of 24-48 months is an established method for selective breeding against IVDD in dogs.
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