Background And Objective: Proximal interphalangeal joint (PIPJ) fractures present significant therapeutic challenges in hand surgery. This systematic review evaluated the comparative efficacy of dynamic external fixation against traditional treatment modalities, integrating machine learning analysis to enhance outcome prediction and treatment selection.
Methods: We systematically reviewed 43 clinical studies published between January 2014 and January 2024, including 26 dynamic external fixations, 6 traditional internal fixations, and 11 static external fixations. Studies were included if they reported quantitative outcomes of PIPJ fracture treatment, had a minimum follow-up of 4 weeks, and included at least 20 patients. Case series with fewer than 5 patients and non-English publications without available translations were excluded. The analysis focused on four key outcomes: range of motion (ROM), recovery time, complication rates, and functional results. We developed a neural network model to predict treatment outcomes, achieving 89.7% accuracy (95% CI 87.3-92.1%). Methodological quality was assessed using the Newcastle-Ottawa Scale and Cochrane Risk of Bias tool.
Results: Dynamic external fixation demonstrated superior outcomes across multiple domains. ROM analysis revealed a median of 86.12° (range: 70°-95°) for dynamic fixation compared to 72.30° (range: 56°-88°) for traditional approaches (mean difference: 13.82°, 95% CI 10.24-17.40°). Dynamic fixation significantly reduced recovery duration (9.68 weeks vs. 20.47 weeks, p < 0.001). Complication profiles favored dynamic fixation, with pin tract infection rates of 2.4% versus 3.8% for traditional fixation. Functional assessment using the Ishida scoring system showed favorable outcomes in the dynamic fixation group, with a mean score of 85.3 points and 78% of cases achieving scores above 80 points.
Discussion: This comprehensive systematic review provides evidence supporting the efficacy of dynamic external fixation for PIPJ fracture treatment. The findings demonstrate improved functional outcomes, accelerated rehabilitation, and reduced complication rates. The integration of machine learning analysis shows promise for optimizing patient-specific treatment selection. Further validation through large-scale, multicenter randomized controlled trials with extended follow-up periods is warranted.
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http://dx.doi.org/10.1186/s13018-025-05644-z | DOI Listing |
Biom J
April 2025
Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China.
Borrowing external controls to augment the concurrent control arm is a popular topic in clinical trials. Bayesian dynamic borrowing methods adaptively discount external controls according to prior-data conflict. For the Gaussian endpoint, parameter-specific information borrowing enables differential discounting between the population mean and variance.
View Article and Find Full Text PDFHippocampus
March 2025
UCL Institute of Cognitive Neuroscience, University College London, London, UK.
Grid and place cells typically fire at progressively earlier phases within each cycle of the theta rhythm as rodents run across their firing fields, a phenomenon known as theta phase precession. Here, we report theta phase precession relative to turning angle in theta-modulated head direction cells within the anteroventral thalamic nucleus (AVN). As rodents turn their heads, these cells fire at progressively earlier phases as head direction sweeps over their preferred tuning direction.
View Article and Find Full Text PDFQuant Plant Biol
February 2025
Marine Biological Association, The Laboratory, Citadel Hill, Plymouth, UK.
Calcium ions (Ca) play pivotal roles in a host of cellular signalling processes. The requirement to maintain resting cytosolic Ca levels in the 100-200 nM range provides a baseline for dynamic excursions from resting levels that determine the nature of many physiological responses to external stimuli and developmental processes. This review provides an overview of the key components of the Ca homeostatic machinery, including known channel-mediated Ca entry pathways along with transporters that act to shape the cytosolic Ca signature.
View Article and Find Full Text PDFPlant Cell Environ
March 2025
State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, China.
Alfalfa (Medicago sativa L.) is a globally cultivated perennial forage legume. Flowering time, an important agronomic trait of alfalfa, is pivotal for farmers to determine the optimal harvest stage, thereby maximizing economic benefits.
View Article and Find Full Text PDFBackground And Objective: Proximal interphalangeal joint (PIPJ) fractures present significant therapeutic challenges in hand surgery. This systematic review evaluated the comparative efficacy of dynamic external fixation against traditional treatment modalities, integrating machine learning analysis to enhance outcome prediction and treatment selection.
Methods: We systematically reviewed 43 clinical studies published between January 2014 and January 2024, including 26 dynamic external fixations, 6 traditional internal fixations, and 11 static external fixations.
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