Purpose: To compare the refractive outcomes and visual quality among different types of astigmatism following SMILE and evaluate effective optical zone (EOZ) features, decentration and their potential effects on visual quality.
Methods: This study included 101 left eyes of 101 patients who underwent SMILE. Patients were grouped according to astigmatism types (with-the-rule [WTR], against-the-rule [ATR] and oblique astigmatism) and decentered displacement (major axis > minor axis and major axis < minor axis). We compared the refractive outcomes, visual quality, EOZ and decentration 3 months postoperatively and analyzed correlations between corneal aberrations and EOZ parameters.
Results: The visual and refractive outcomes were favorable in different types of astigmatism. The induced corneal aberrations, EOZ and total decentration were comparable among three groups (all p >.05). There was a strong positive correlation (r =.828, p <.001) between preoperative cylinder axis and the angle of EOZ. The postoperative induced changes in spherical aberration (0.02 ± 0.15 vs. 0.08 ± 0.13, p =.037), coma (0.22 ± 0.27 vs. 0.36 ± 0.25, p =.010), total HOAs (0.28 ± 0.24 vs. 0.42 ± 0.31, p =.009) and LOAs (0.16 ± 0.62 vs. 0.49 ± 0.84, p =.023) were fewer in group with greater decentered displacement along the major axis than the minor axis.
Conclusions: Favorable outcomes were observed in different types of astigmatism. Postoperative refractive errors, visual acuity, and induced corneal aberrations showed no significant differences between groups with WTR, ATR, and oblique astigmatism. The angle of EOZ was closely associated with cylinder axis. EOZ provided greater tolerance to decentration, with fewer induced corneal aberrations along the major axis compared to the minor axis. The combined impacts of EOZ and decentration on visual quality should be noted.
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http://dx.doi.org/10.1186/s12886-025-03948-6 | DOI Listing |
Cornea
March 2025
Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Purpose: To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD).
Methods: Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital.
Proc Natl Acad Sci U S A
March 2025
Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.
Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is regulated by structural changes in both filaments. Thin filaments are activated by an increase in intracellular calcium concentration [Ca] and by myosin binding to actin. Thick filaments are activated by direct sensing of the filament load.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.
View Article and Find Full Text PDFNanoscale
March 2025
School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510640, China.
Raman spectroscopy has demonstrated significant potential in molecular detection, analysis, and identification, particularly when it adopts single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. A recent SM-SERS scheme incorporates two-fold Raman enhancement mechanisms: the electromagnetic enhancement enabled by a plasmonic nanogap hotspot formed from gold sphere nanoparticles sitting on a gold mirror and the chemical enhancement enabled by a two-dimensional material, WS, inserted into the nanogap. In this work we integrate multiple advanced concepts and techniques to achieve remarkable performance improvements of SM-SERS.
View Article and Find Full Text PDFOphthalmol Ther
March 2025
Team "Staphylococcal Pathogenesis", CIRI - Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of sight-threatening infections in the US. These strains pose a significant challenge in managing ocular infections, as they frequently exhibit resistance to first-line empirical antibiotics. To assess the potential of bacteriophages as innovative topical therapies for treatment of recalcitrant ocular infections, we evaluated the in vitro antimicrobial activity of a set of anti-S.
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