Background: Hepatitis B immunoprophylaxis reduces the rate of mother-to-child transmission of hepatitis B virus infection and has effectively reduced the global burden of the hepatitis B virus infection. However, the cost of hepatitis B immunoglobulin could be prohibitive hampering adequate utilization in pregnancy and childbirth. Cost may affect pregnant women's willingness to pay (WTP) for the immunoglobulin. The WTP for hepatitis B immunoglobulin has not been critically studied in Enugu, Nigeria. The objective of the study was to determine the willingness of pregnant women to pay for hepatitis B immunoglobulin and to identify the predictors of the level of WTP among pregnant women in Enugu, Nigeria.
Methods: A cross-sectional study that involved 379 pregnant women who were selected through a multi-stage sampling technique from the health facilities in Enugu between March and November 2019 was conducted. A structured pre-tested interviewer-administered questionnaire was used for data collection. The contingent valuation technique was utilized for eliciting values attached to hepatitis B immunoglobulin by the pregnant women while the bidding game technique was used to determine the maximum amounts the participants were willing to pay. Data were analyzed using SPSS version 23. A p-value of 0.05 was regarded as significant.
Results: Most respondents (86.2%) were willing to pay for the hepatitis B immunoglobulin. The mean maximum amount of WTP was ₦23178.34 (62.64 USD). The price of hepatitis B immunoglobulin (48.8%) was a major hindrance to WTP and 36.9% of the respondents believed that the government should pay for the vaccines. Predictors of the average WTP amount were the level of education (p = 0.038, AOR = 2.645 CI: 1.055-6.630), participants' husbands' occupation, and weekly expenditure on food items (P = 0.041; AOR = 3.828, CI: 1.055-13.893).
Conclusions: The rate of WTP for hepatitis B immunoglobulin was 86.2%, however, the mean WTP amount was far below the market value of hepatitis B immunoglobulin. The major hindrance to WTP was the cost of the vaccine as most participants believed that the vaccine should be administered freely and financed by the government and its agencies. The predictors of willingness to pay were the participant's level of education, husband's occupation and weekly expenditure on food.
Trial Registration: Not applicable.
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http://dx.doi.org/10.1186/s12884-025-07386-6 | DOI Listing |
Cells
February 2025
Fiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
Several immunoregulatory or immune checkpoint receptors including T cell immunoglobulin and mucin domain 3 (TIM-3) have been implicated in glioblastoma progression. Rigorous investigation over the last decade has elucidated TIM-3 as a key player in inhibiting immune cell activation and several key associated molecules have been identified both upstream and downstream that mediate immune cell dysfunction mechanistically. However, despite several reviews being published on other immune checkpoint molecules such as PD-1 and CTLA-4 in the glioblastoma setting, no such extensive review exists that specifically focuses on the role of TIM-3 in glioblastoma progression and immunosuppression.
View Article and Find Full Text PDFRheumatology (Oxford)
March 2025
Norwich Medical School, University of East Anglia, Norwich, UK.
Polyarteritis nodosa (PAN) was first described in 1852 with the first widely recognised description in 1866 by Kussmaul and Meier. Since then our concepts of the condition have evolved, with recognition of the difference between polyarteritis nodosa and microscopic polyangiitis (MPA). Classification criteria for PAN remain unsatisfactory.
View Article and Find Full Text PDFPediatr Rheumatol Online J
March 2025
Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey.
Background: Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and is used in combination with systemic corticosteroids in the treatment of many childhood rheumatic diseases, such as systemic lupus erythematosus (SLE), and ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged as a new alternative treatment modality over CYC for induction therapy of childhood-onset rheumatic diseases. Clinicians adopt different practices for using CYC particularly in relation to indications, posology, pre-treatment laboratory work-up, post-treatment follow-up, and screening pre- and post-treatment vaccination status.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
March 2025
Department of Health Administration and Management, University of Nigeria, Enugu Campus, Enugu, Nigeria.
Background: Hepatitis B immunoprophylaxis reduces the rate of mother-to-child transmission of hepatitis B virus infection and has effectively reduced the global burden of the hepatitis B virus infection. However, the cost of hepatitis B immunoglobulin could be prohibitive hampering adequate utilization in pregnancy and childbirth. Cost may affect pregnant women's willingness to pay (WTP) for the immunoglobulin.
View Article and Find Full Text PDFPediatr Infect Dis J
March 2025
National Centre for Immunisation Research and Surveillance, Westmead, New South Wales, Australia.
Background: A birth acellular pertussis vaccine may be a valuable alternative for immunity against infant pertussis when a pregnancy pertussis vaccine has not been administered. We assessed whether a birth dose may impair immunoglobulin G (IgG) responses to childhood pertussis boosters.
Methods: Children from our previous randomized controlled trial who received a monovalent 3-component aP and hepatitis B vaccine at birth (aP group) or hepatitis B only (control group) followed by Infanrix hexa at 2, 4 and 6 months of age were randomized to receive either high or low-dose diphtheria-tetanus acellular pertussis combination vaccine (DTPa-Infanrix/dTpa-Boostrix) at 18 months and 4 years of age.
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