Objective: This study aimed to investigate the relationship between body mass index (BMI) during adolescence and the future risk of developing hypertension, with a particular focus on potential sex differences.
Methods: This study was a secondary analysis based on a cohort study involving 2,020 adolescents aged 10-15 years who underwent health check-ups at the MJ Health Screening Center between 1999 and 2008. Cox proportional hazards regression models were used to evaluate the association between BMI and hypertension risk, with stratification by gender. Cox proportional hazards regression with cubic spline functions was employed to explore potential nonlinear relationships, and sensitivity analyses were conducted to ensure robustness.
Results: The multivariate Cox proportional hazards regression model showed a significant positive association between BMI and hypertension risk in the overall adolescent population and particularly in males, with hazard ratios (HRs) of 1.204 (95% CI: 1.038-1.396) and 1.181 (95% CI: 1.013-1.377), respectively. In females, a nonlinear relationship with a threshold effect was identified, with an inflection point at a BMI of 24.11 kg/m². Beyond this threshold, each 1 kg/m² increase in BMI was associated with a 3.491-fold higher risk of hypertension (HR = 4.491, 95% CI: 1.185-17.020).
Conclusion: Among Chinese adolescent males, there was a positive dose-response relationship between BMI and future hypertension risk. In adolescent females, a specific nonlinear association with a threshold effect (inflection point: 24.11 kg/m²) was observed. Maintaining a BMI below 24.11 kg/m² in adolescent females may reduce their future risk of developing hypertension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1186/s12887-025-05555-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parental Input and Its Relationship With Language Outcomes in Children With (Suspected) Developmental Language Disorder: A Systematic Review.
J Speech Lang Hear Res
March 2025
Department of Education and Pedagogy, Faculty of Social and Behavioural Sciences, Utrecht University, the Netherlands.
Purpose: It is widely acknowledged that parental input plays an important role in typical language development. Less is known about the input provided to children with (suspected) developmental language disorder (DLD) or those at risk for DLD. These children may not benefit from parental input in the same way as their typically developing peers, and different aspects of parental input may be more important for them.
View Article and Find Full Text PDFLong term latency of highly mutated cells in normal mouse skin is reversed by exposure to tumor promoters and chronic tissue damage.
Cancer Discov
March 2025
University of California, San Francisco, San Francisco, CA, United States.
Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. Here, we carried out whole genome sequencing to demonstrate that initiated cells with thousands of mutagen-induced mutations can persist for long periods and are not removed by cell competition or by immune intervention, thus mimicking the persistence of cells with cancer driver mutations in normal human tissues.
View Article and Find Full Text PDFType A Aortic Dissection Following Abdominal Solid Organ Transplantation: Population-Level Outcomes in the United States.
Clin Transplant
March 2025
Division of Cardiac Surgery, CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA.
Background: This study aims to analyze the patient characteristics, clinical outcomes, and contemporary trends concerning type A aortic dissection (TAAD) in previous recipients of abdominal solid organ transplantation (ASOT) in the United States.
Methods: The National Inpatient Sample was queried to identify all patients aged ≥18 with TAAD and a history of ASOT (TAAD-ASOT) between 2002 and 2015Q3 using ICD-9 diagnosis and procedure codes. Baseline characteristics and in-hospital outcomes were compared between TAAD-ASOT patients and TAAD patients without a history of ASOT (TAAD-non-ASOT).
Urinary Biomarkers and Attainment of Cefepime Therapeutic Targets in Critically Ill Children.
Pediatr Infect Dis J
March 2025
From the Department of Pediatrics.
Background: Critically ill children are at risk for subtherapeutic antibiotic concentrations. The frequency of target attainment and risk factors for subtherapeutic concentrations of cefepime in children have not been extensively studied.
Methods: We performed an observational study in critically ill children receiving a new prescription of standard dosing of cefepime for suspected sepsis (≥2 systemic inflammatory response syndrome criteria within 48 hours of cefepime start).
Navigating Dual-Harm: Integrating Self- and Other-Harm Into Public Health Inquiry.
Am J Public Health
April 2025
Diego A. Díaz-Faes and Charles C. Branas are with the Mailman School of Public Health and Sonali Rajan is with Teachers College, Columbia University, New York, NY.
Dual-harm, the co-occurrence of self- and other-harm, recognizes the overlap between these outcomes of aggressive behavior and their potential shared causes. Little progress has been made in preventing and responding to dual-harm in the broader population, and it remains understudied in public health research. We posit that the scientific investigation of dual-harm would greatly benefit from the application of public health principles and methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!