An increasing number of real-world interventions aim to preemptively protect or inoculate people against misinformation. Inoculation research has demonstrated positive effects on misinformation resilience when measured immediately after treatment via messages, games, or videos. However, very little is currently known about their long-term effectiveness and the mechanisms by which such treatment effects decay over time. We start by proposing three possible models on the mechanisms driving resistance to misinformation. We then report five pre-registered longitudinal experiments (N = 11,759) that investigate the effectiveness of psychological inoculation interventions over time as well as their underlying mechanisms. We find that text-based and video-based inoculation interventions can remain effective for one month-whereas game-based interventions appear to decay more rapidly-and that memory-enhancing booster interventions can enhance the diminishing effects of counter-misinformation interventions. Finally, we propose an integrated memory-motivation model, concluding that misinformation researchers would benefit from integrating knowledge from the cognitive science of memory to design better psychological interventions that can counter misinformation durably over time and at-scale.
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http://dx.doi.org/10.1038/s41467-025-57205-x | DOI Listing |
Br Poult Sci
March 2025
State Key Laboratory for Quality and Safety of Agro-products, Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
1. The avian gut hosts a complex and dynamic microbial ecosystem, which is essential for regulating host organ function. However, the relationship between the gut microbiota and the hypothalamic axis in acute stress vulnerability in ducks remains unclear.
View Article and Find Full Text PDFCell Death Discov
March 2025
Institute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore" (IEOMI), Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
The tumor microenvironment profoundly influences tumor complexity, particularly in breast cancer, where cancer-associated fibroblasts play pivotal roles in tumor progression and therapy resistance. Extracellular vesicles are involved in mediating communication within the TME, specifically highlighting their role in promoting the transformation of normal fibroblasts into cancer-associated fibroblasts. Recently, we identified an RNA aptamer, namely ex.
View Article and Find Full Text PDFNat Commun
March 2025
Department of Psychology, University of Cambridge, Cambridge, UK.
An increasing number of real-world interventions aim to preemptively protect or inoculate people against misinformation. Inoculation research has demonstrated positive effects on misinformation resilience when measured immediately after treatment via messages, games, or videos. However, very little is currently known about their long-term effectiveness and the mechanisms by which such treatment effects decay over time.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
March 2025
Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.
Gap Junctions channels formed by Connexins (Cx) provide intercellular communication enabling the coordination of cell growth, differentiation, and metabolism, and their reduction has been shown in many tumor types. Expression levels of Cx43, the most extensively studied Gap Junctions forming protein, are reduced or completely absent in breast cancer cells, while their overexpression correlates with increased cellular permeability to anticancer agents and, consequently, reduced resistance to drug treatments. So, drug associations targeting Cx43 are being considered to overcome chemoresistance.
View Article and Find Full Text PDFGut Microbes
December 2025
Center for Microbial Ecology and Technology (CMET), Department of Biotechnology, Ghent University, Gent, Belgium.
Antibiotic resistance is a rising problem and new and sustainable strategies to combat bacterial (intestinal) infections are therefore urgently needed. One promising strategy under intense investigation is the inhibition of quorum sensing, bacterial cell-to-cell communication with small molecules. A key question with respect to the application of quorum sensing inhibition is whether it will impose selective pressure for the spread of resistance.
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