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Sensing the Future of Thrombosis Management: Integrating Vessel-on-a-Chip Models, Advanced Biosensors, and AI-Driven Digital Twins.
ACS Sens
March 2025
School of Biomedical Engineering, The University of Sydney,Darlington,NSW 2008,Australia.
Thrombotic events, such as strokes and deep vein thrombosis, remain a significant global health burden, with traditional diagnostic methods often failing to capture the complex, patient-specific nuances of thrombosis risk. This Perspective explores the revolutionary potential of microengineered vessel-on-chip platforms in thrombosis research and personalized medicine. We discuss the evolution from basic microfluidic channels to advanced 3D-printed, patient-specific models that accurately replicate complex vascular geometries, incorporating all elements of Virchow's triad.
View Article and Find Full Text PDFEvaluation of a digital reporting and supporting tool in breast cancer prevention trials (KarmApp).
BMC Health Serv Res
March 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12 A, Stockholm, 171 77, Sweden.
Background: Anti-estrogens are widely used to reduce recurrence in breast cancer patients. The side effects often lead to treatment non-adherence and the use of anti-hormonal treatments as primary prevention in women with increased risk of breast cancer is very low. We have conducted breast cancer prevention trials aiming to lower the adverse effects of anti-hormones, but with retained effect.
View Article and Find Full Text PDFHigh-resolution 3D visualization of human hearts with emphases on the cardiac conduction system components-a new platform for medical education, mix/virtual reality, computational simulation.
Front Med (Lausanne)
February 2025
Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester, United Kingdom.
Introduction: High-resolution digitized cardiac anatomical data sets are in huge demand in clinical, basic research and computational settings. They can be leveraged to evaluate intricate anatomical and structural changes in disease pathology, such as myocardial infarction (MI), which is one of the most common causes of heart failure and death. Advancements in high-resolution imaging and anatomical techniques in this field and our laboratory have led to vast improvements in understanding cardiovascular anatomy, especially the cardiac conduction system (CCS) responsible for the electricity of the heart, in healthy/aged/obese post-mortem human hearts.
View Article and Find Full Text PDFAdvancing Medical Innovation through Blockchain-Secured Federated Learning for Smart Health.
IEEE J Biomed Health Inform
January 2025
The rapid digitization of healthcare systems has led to a vast accumulation of electronic medical records (EMRs), offering an invaluable source of patient data that can significantly advance medical research and improve patient care. However, sharing EMRs for research purposes presents challenges, particularly concerning data privacy, security, and the limitations of traditional centralized data-sharing models. This paper introduces a novel approach that leverages blockchain technology to facilitate federated learning with EMRs, thereby addressing these challenges.
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