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Fueling defense: PPARα enhances macrophage inflammatory responses.
Cell Mol Immunol
March 2025
Department of Medical Biochemistry, Amsterdam institute for Immunology and Infectious Diseases, Immunology, Amsterdam Cardiovascular Sciences, Atherosclerosis, Amsterdam UMC, location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth.
Nat Commun
March 2025
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing or decreasing the risk of sepsis, respectively. Here, combined transcriptomic, metabolic, and immunological studies in monocytes of healthy individuals reveal an inverse ontogenetic shift in metabolic pathway activities with increasing age.
View Article and Find Full Text PDFToxicological screening of PM from wildfires involving different biomass fuels.
Environ Pollut
April 2025
Centre for Environmental and Marine Studies, Department of Environment, University of Aveiro, 3810-193, Aveiro, Portugal.
Wildfires are becoming increasingly frequent and severe, particularly in Southern Europe. In addition to their immediate environmental and socioeconomic impacts, wildfires release significant amounts of particulate matter (PM), which poses serious health and ecological risks. Gaseous (CO and CO) and PM samples were collected directly from smoke plumes, and the modified combustion efficiency (MCE) was calculated to characterise combustion conditions.
View Article and Find Full Text PDF"No Matter the Age or Medical Complexity, People Benefit From That Intensity of Exercise": A Mixed-Methods Study Describing Rehabilitation Provider Perceptions of High-Intensity Resistance Training Among Veterans Receiving Post-Acute Care.
J Geriatr Phys Ther
January 2025
VA Eastern Colorado Geriatric Research Education and Clinical Center (GRECC), VA Eastern Colorado Health Care System, Aurora, Colorado.
Background: In skilled nursing facilities (SNFs), i-STRONGER is a novel, high-intensity resistance training approach that incorporates progressive resistance training to promote greater improvements in patient function compared to usual care. To inform large-scale expansion of i-STRONGER as standard-of-care in SNFs, this mixed-methods study assessed rehabilitation providers' perceptions of i-STRONGER and purported needs for its adoption.
Methods: Forty-three rehabilitation providers participated in an 18-week, interactive i-STRONGER training program.
The emerging fungal pathogen induces IFNγ to colonize mammalian hair follicles.
bioRxiv
January 2025
Department of Microbiology & Immunology, University of California, San Francisco; San Francisco, CA, USA.
Public health alarm concerning the emerging fungus is fueled by its antifungal drug resistance and propensity to cause deadly outbreaks. Persistent skin colonization drives transmission and lethal sepsis although its basis remains mysterious. We compared the skin colonization dynamics of with its relative , quantifying skin fungal persistence and distribution and immune composition and positioning.
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