The Effect of Rosuvastatin and Calcitriol on Preventing Voice Change After Thyroidectomy: A Randomized Controlled Trial.
J Voice
Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Published: March 2025
Hypothesis: Thyroidectomy is a procedure for treatment of thyroid lesions. A common adverse effect is voice change that impairs the patient's well-being. This study aimed to investigate the effect of Rosuvastatin and Calcitriol on preventing voice change after thyroidectomy.
Study Design: This is a parallel, single-blinded, block-randomized controlled trial in a tertiary medical center in southern Iran, Shiraz.
Methods: Adult patients scheduled for total thyroidectomy in 2023 were randomly assigned to one of three groups: Rosuvastatin, Rosuvastatin and Calcitriol, or no anti-inflammatory medication starting 14 days before surgery. The surgeon and the individuals who collected the data were blinded to the allocated groups. Voice change was evaluated 2 weeks after surgery. Written consent was obtained.
Results: In total, 177 patients were included in this study, 29 (16.4%) males and 148 (83.6%) females. In total, 66 (37.3%) received Rosuvastatin and Calcitriol, 54 (30.5%) received only Rosuvastatin, and 57 (32.2%) did not receive any medication 2 weeks prior to surgery. Consequently, 123 (69.5%), 42 (23.7%), and 12 (6.8%) had minimal, moderate, and severe voice disorder. Voice change was not significantly different among patients who received Rosuvastatin and Calcitriol and Rosuvastatin alone compared with the group with no drugs (P value = 0.199 and 0.646, respectively).
Conclusion: This study suggests that there was no difference in the severity of voice change or in the components of the Voice Handicap Index between patients who received medication and those who did not. Further investigations are warranted to optimize patients' outcomes and quality of life after thyroidectomy.
Trial Registration Number: IRCT20230711058741N1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jvoice.2025.02.033 | DOI Listing |
Similar Publications
Efficacy and safety of PD-1/PD-L1 inhibitors alone or in combination in the treatment of metastatic or advanced renal cell carcinoma: a network meta-analysis.
Front Immunol
March 2025
Second Department of Urology and Surgery, Affiliated Hospital of Hebei Engineering University, Handan, China.
Background: This study systematically reviews the efficacy and safety of the single or combined use of programmed factor 1 (PD-1)/programmed factor 1 ligand (PD-L1) inhibitors for treating metastatic or advanced renal cell carcinoma (RCC).
Methods: Relevant articles were collected for meta-analysis through searches on PubMed, Web of Science, Embase, Cochrane Library, and Clinical Trials, as well as for relevant randomized controlled experiments.
Results: Based on eleven studies, the effectiveness of the experimental group was found to be significantly better than the control in terms of overall survival (OS) [R=0.
Acid Assault: Unmasking the Toll of Laryngopharyngeal Reflux Disease on Vocal Health - A Literature Review.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pillaiyarkuppam, Pondicherry, 607402 India.
Laryngopharyngeal reflux disease (LPRD) is characterized by the backflow of gastric contents into the laryngopharynx, distinct from gastroesophageal reflux disease (GERD). Prevalence among otolaryngology patients ranges from 4 to 30% and being the major cause for hoarseness of voice. Common symptoms include hoarseness, chronic coughing, globus sensation, throat clearing and endoscopic evaluation reveals signs like posterior commissure hypertrophy and vocal fold edema.
View Article and Find Full Text PDFSinonasal and Laryngeal Presentations of Pituitary Adenoma.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104 India.
Pituitary adenomas, the second most common intracranial pathology, often exhibit symptoms beyond the classic triad of headache, visual disturbances, and hormonal imbalances. Unusual presentations involve sinonasal pathology, cranial nerve involvement, and mass effects on adjacent structures like the skull base. Secretory adenomas may manifest hormonal changes and their effects.
View Article and Find Full Text PDFNavigating a Giant Thyroglossal cyst: A Compelling Case Study.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Sant Tukaram Nagar, Pimpri, Pune, 411 018 Maharashtra India.
Thyroglossal duct cysts are congenital neck cysts, formed as a result of the failure of the thyroglossal duct to involute during embryogenesis. We present a case of a 55- year-old male who presented with a history of a large anterior neck mass measuring 11 x 8.5 cm.
View Article and Find Full Text PDFEffect of medical mask on voice in patients with dysphonia.
World J Otorhinolaryngol Head Neck Surg
March 2025
Department of Otolaryngology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Objective: Medical masks have been shown to significantly influence speech communication in healthy people. The effect of mask-wearing on phonatory capability and daily communication exchanges in patients with voice disorders remains unclear. To evaluate the effect of the medical mask on acoustic parameters in patients with a voice disorder, we measured the voice frequency, quality, and intensity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.