To improve the settling time for high-speed point-to-point motion, a piecewise-model feedforward controller is introduced which utilizes multiple inverse sub-models with bumpless transfer between them. As the transfer function of this bumpless feedforward controller is non-commutative and non-invertible, a set of special perturbation and reference inputs are designed to extract the signals required for computing the gradient of the cost function. In this way, the optimal parameters within different motion phases are found within an integrated process. It is experimentally demonstrated in a wire-bonding machine that the root-mean-square of tracking error is improved by at least 15.3% in settling phase by the proposed data-based tuning method with bumpless feedforward controller, compared with existing tuning methods with uniform feedforward controller.
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http://dx.doi.org/10.1016/j.isatra.2025.02.028 | DOI Listing |
The ability to adjust movements in response to perturbations is key for an efficient and mature nervous system, which relies on two complementary mechanisms - feedforward adaptation and feedback control. We examined the developmental trajectory of how children employ these two mechanisms using a previously validated visuomotor rotation task, conducted remotely in a large cross-sectional cohort of children aged 3-17 years and adults (n = 656; 353 males & 303 females). Results revealed a protracted developmental trajectory, with children up to ~13-14 years showing immature adaptation.
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March 2025
Department of Mechanical, Materials and Manufacturing Engineering, The University of Nottingham Ningbo China, 199 Taikang East Road, Ningbo, 315100, Zhejiang, China; Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, The University of Nottingham Ningbo China, 199 Taikang East Road, Ningbo, 315100, Zhejiang, China. Electronic address:
To improve the settling time for high-speed point-to-point motion, a piecewise-model feedforward controller is introduced which utilizes multiple inverse sub-models with bumpless transfer between them. As the transfer function of this bumpless feedforward controller is non-commutative and non-invertible, a set of special perturbation and reference inputs are designed to extract the signals required for computing the gradient of the cost function. In this way, the optimal parameters within different motion phases are found within an integrated process.
View Article and Find Full Text PDFCell Discov
March 2025
Faculty of Healthy Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macau, China.
PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly focused on its post-translational modifications, while the transcriptional regulation of PINK1 is much less understood. Herein, we reported a novel mechanism in control of PINK1 transcription by SMAD Family Member 3 (SMAD3), an essential component of the transforming growth factor beta (TGFβ)-SMAD signaling pathway.
View Article and Find Full Text PDFElife
March 2025
Ache Lab, Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, Würzburg, Germany.
Insulin plays a critical role in maintaining metabolic homeostasis. Since metabolic demands are highly dynamic, insulin release needs to be constantly adjusted. These adjustments are mediated by different pathways, most prominently the blood glucose level, but also by feedforward signals from motor circuits and different neuromodulatory systems.
View Article and Find Full Text PDFHum Brain Mapp
March 2025
Institute of Health and Neurodevelopment (IHN) and School of Psychology, Aston University, Birmingham, UK.
Negative BOLD fMRI responses (NBR) occur commonly in sensory cortex and default mode network regions but remain poorly utilized as a marker of brain function due to an incomplete understanding. To better understand how NBR manifest across the brain, compare between different sensory stimuli and how they are modulated by changes in task demand, we recorded fMRI during trials of visual, auditory, or somatosensory stimulation, delivered either alone or in concurrent pairs. Twenty young-adult participants were cued to attend to a single modality and detect targets in each trial.
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