While most SARS-CoV-2 infections and reinfections in the era of widespread population immunity with omicron subsub-lineage variants are mild for immunocompetent individuals, any manifestation previously seen during the pandemic phase is still possible. COVID-19 may affect any organ system. Previous infections and prior vaccines protect against symptomatic future SARS-CoV-2 infections, though this protection wanes over time.
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Clinical Manifestations of SARS-CoV-2 Infection in Immunocompetent Adults in the Era of Widespread Population Immunity and Omicron Sublineage Viruses.
Infect Dis Clin North Am
March 2025
Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA; Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:
While most SARS-CoV-2 infections and reinfections in the era of widespread population immunity with omicron subsub-lineage variants are mild for immunocompetent individuals, any manifestation previously seen during the pandemic phase is still possible. COVID-19 may affect any organ system. Previous infections and prior vaccines protect against symptomatic future SARS-CoV-2 infections, though this protection wanes over time.
View Article and Find Full Text PDFMammalian Species-Specific Resistance to Mammary Cancer.
J Mammary Gland Biol Neoplasia
March 2025
Institute of Animal Science, ARO, The Volcani Center, Bet Dagan, Israel.
Tumorigenesis in mammals is driven by inherited genetic variants, environmental factors and random errors during normal DNA replication that lead to cancer-causing mutations. These factors initiate uncontrolled cellular proliferation and disrupt the regulation of critical checkpoints. A few mammalian species possess unique protective mechanisms that enable them to resist widespread cancer development and achieve longevity.
View Article and Find Full Text PDFRecent Guidelines and Perspectives for Varicocele: A Clinical Consensus and Recommendations from the Korean Society for Sexual Medicine and Andrology.
World J Mens Health
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Department of Urology, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Varicocele is a common urological disease and varicocele has long been recognized as a condition that could affect male fertility. Although varicocele is the most common surgically correctable cause of male infertility, not all varicoceles require treatment. Because the appropriate diagnosis and management of varicoceles remain less clear in many patients, it is important to diagnose clinically significant varicoceles that can benefit from treatment.
View Article and Find Full Text PDFThe New Era of Cost Analysis in Spine Surgery Utilizing Time-Driven Activity Based Costing: A Systematic Review and Introduction of an Enabling Technology Value Index.
Spine J
March 2025
Center for Neurosciences and Spine, Department of Neurosurgery, Virginia Mason Franciscan Health, Seattle, WA, USA.
Background Context: Recent studies have demonstrated that time driven activity-based costing (TDABC) may be able to provide a robust and reproducible mechanism that can detect variability of time-based care within several areas of spine care.
Purpose: The purpose of this systematic review is to provide a summary of the growing applications of TDABC in spine care and introduce a value index in which it can be applied to rigorously evaluate various innovations in a reproducible and accurate fashion.
Study Design: Systematic Review METHODS: : The authors performed a systematic literature search of the PubMed and Embase databases using search terms related to spine surgery and TDABC.
[Bacterial viruses in the Anthropocene era: friends or enemies of their hosts ?].
Med Sci (Paris)
February 2025
INRAE, université de Bordeaux, UMR 1366 oenologie, Bordeaux INP ISVV, Bordeaux, France.
Bacterial viruses, or bacteriophages, are the most abundant viruses on Earth, and their hosts are the most widespread living organisms in the biosphere. They are found in a free state, as virions, but are also very abundant in bacterial genomes, as prophages. Bacteriophages are present in all biotopes colonized by bacteria, such as water, soils, extreme environments, human, animal, and plant microbiomes, where they contribute to genetic exchanges.
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