Background: Sustainable development goals (SDGs) may play a pivotal role in mitigating antimicrobial resistance (AMR). This study examines how countries can integrate AMR mitigation with sustainable development strategies, providing evidence on the prioritisation of AMR-related efforts within both agendas.
Methods: We conducted a comparative analysis of the international global action plan (GAP) and national action plan (NAP) on AMR and SDGs across 10 countries in Africa and Asia. We employed content analysis to map actions to AMR drivers, descriptive statistics to summarise the coverage and focus of the actions and inferential statistics to explore factors associated with the level of policy alignment.
Results: Our findings highlight gaps in the current AMR policy landscape, where drivers are at risk of being redundantly addressed, narrowly focused or entirely overlooked. At the international level, over 50% of AMR drivers are addressed by both frameworks, but national-level overlap is lower (10.5%-47.4%), with Asian countries showing stronger alignment than African countries. Asian countries show a higher proportion of shared drivers than African countries. A considerable proportion of drivers are addressed solely by AMR-NAPs (23.7%-60.5%) or SDG-NAPs (13.2%-31.6%), raising concerns that actions may benefit either sustainable development or AMR at the expense of the other. Finally, 10.5%-26.3% of drivers, mostly distal, are not acknowledged by either framework, highlighting potential policy blind spots.
Conclusions: The Agenda 2030 includes ambitious and cross-cutting goals with GAP-AMR, therefore it can facilitate intersectoral collaboration in addressing AMR. The effective implementation of both agendas will depend on national governments' capacity to ensure that efforts in combating AMR also contribute to sustainable development.
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http://dx.doi.org/10.1136/bmjgh-2024-017837 | DOI Listing |
J Immunol
January 2025
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China.
The von Hippel-Lindau (VHL) tumor suppressor gene VHL is a classic tumor suppressor that has been identified in family members with clear cell renal cell carcinomas, central nervous system and retinal hemangioblastomas, phaeochromocytomas, and pancreatic neuroendocrine tumors. The well-defined function of VHL is to mediate proteasomal degradation of hydroxylated hypoxia-inducible factor α proteins, resulting in the downregulation of hypoxia-responsive gene expression. Previously, we reported that VHL inhibits antiviral signaling by targeting mitochondrial antiviral signaling protein (MAVS) for proteasomal degradation.
View Article and Find Full Text PDFAn Acad Bras Cienc
March 2025
Escola Politécnica da Universidade de São Paulo, Av. Prof. Almeida Prado - Travessa 2, n. 83, Cidade Universitária, 05508-070 São Paulo, SP, Brazil.
This article addresses gender issues in the context of the professor's productivity grants (PQ) distribution applied to Civil Engineering. It contributes with reflections on the advancement of knowledge and gender equality through the inclusion of integrity and holistic aspects. A quantitative and descriptive data analysis of public documents revealed that the number of women civil engineers is considerable, and that female professors engaged in postgraduate are capable of competing for scholarships.
View Article and Find Full Text PDFPLoS One
March 2025
Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, México.
The 2030 Agenda for Sustainable Development of the United Nations outlines 17 goals for countries of the world to address global challenges in their development. However, the progress of countries towards these goal has been slower than expected and, consequently, there is a need to investigate the reasons behind this fact. In this study, we have used a novel data-driven methodology to analyze time-series data for over 20 years (2000-2022) from 107 countries using unsupervised machine learning (ML) techniques.
View Article and Find Full Text PDFEnviron Monit Assess
March 2025
Department of Civil, Environment & Geomatic Engineering, University College London (UCL), Gower Street, London, WC1E 6BT, UK.
Industrialization and population explosion are ultimately affecting freshwater resources. Bahawalpur is a rapidly growing city in Pakistan where groundwater is the major source of drinking water. However, groundwater is also being contaminated due to various anthropogenic sources.
View Article and Find Full Text PDFVet Res Commun
March 2025
Faculdade de Ciências Agrarias e Veterinária (FCAV), Universidade Estadual de São Paulo (Unesp), Jaboticabal, São Paulo, Brasil.
The present study aimed to evaluate the effectiveness of a new formulation composed of the chemical active ingredients benzoylphenylurea, phenylpyrazole and macrocyclic lactone, which have different mechanisms of action on the most important parasites, such as R. microplus, H. irritans, D.
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