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http://dx.doi.org/10.1136/bmj.r468 | DOI Listing |
Anal Chim Acta
May 2025
State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning, Guangxi, 530004, PR China; College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004, PR China; Medical College of Guangxi University, Guangxi University, Nanning, Guangxi, 530004, PR China; Center for Instrumental Analysis, Guangxi University, Nanning, Guangxi, 530004, PR China. Electronic address:
Tryptophan (Trp) is an essential amino acid obtained from human diet. It is involved not only in de novo biosynthesis of proteins but also in complex metabolic pathways. Redox transformation of tryptophan is under-explored in comparison with kynurenine, serotonin and indole pyruvate pathways.
View Article and Find Full Text PDFChemosphere
March 2025
Environmental Microbiology Group, Institute of Water Research, University of Granada, Granada, 18003, Spain; Department of Microbiology, University of Granada, Granada, 18071, Spain.
There is increasing awareness of the presence of anticancer drugs (ACDs) in wastewater. Nonetheless, how ACDs affect the performance of wastewater treatment systems and their microbial populations remains largely unclear. This study investigated the effects of three common ACDs (cyclophosphamide, tamoxifen, and methotrexate) at varying concentrations on physicochemical parameters and drug removal efficiency in an aerobic granular sludge (AGS) system operated in a continuous-flow reactor.
View Article and Find Full Text PDFMed Image Anal
March 2025
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
This study addresses the challenges of confounding effects and interpretability in artificial-intelligence-based medical image analysis. Whereas existing literature often resolves confounding by removing confounder-related information from latent representations, this strategy risks affecting image reconstruction quality in generative models, thus limiting their applicability in feature visualization. To tackle this, we propose a different strategy that retains confounder-related information in latent representations while finding an alternative confounder-free representation of the image data.
View Article and Find Full Text PDFOrg Lett
March 2025
Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, and School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002, People's Republic of China.
The Cu(II)-catalyzed -heteroannulation reaction of [60]fullerene (C) with aryl sulfonamides and paraformaldehyde has been disclosed for the synthesis of diverse C-fused imidazolidines, of which one or both of the ArSO moieties could be removed selectively. Further transformations into the unexpected bicyclic 1,2,3,4-adduct and C-fused imidazolidinium iodide salt have also been demonstrated. A plausible reaction mechanism is proposed on the basis of control experiments.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Currently, most cell or tissue transplantations using induced pluripotent stem cells (iPSCs) are anticipated to involve allogeneic iPSCs. However, the immunological properties of iPSCs in an allogeneic setting are not well understood. We previously established a mouse transplantation model of MHC-compatible/minor antigen-mismatched combinations, assuming a hypoimmunogenic iPSC-setting.
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