Objective: To describe the clinical spectrum of pediatric and adolescent patients infected with Chikungunya.
Methods: Cross-sectional study with patients aged 0 to 17 years hospitalized with a Chikungunya Fever diagnosis in Ceará, in 2017. Data were collected on the clinical manifestations associated with the condition; significant differences were considered when p < 0.05.
Results: Fever (100%), erythrodermic rash (90.48%), and arthralgia (52.38%) were the most frequent symptoms. Arthralgia was more prevalent in children older than over five years (86.36%), and irritability and the bullous rash were predominant in children younger than five years (p < 0.05). The most predominant non-specific manifestations were: myalgia (28.57%), oral lesions (28.57%), and abdominal pain (26.19%). Neurological complications were observed in 14.29% of the patients, bacterial complications in 11.90%, Kawasaki disease in 4.76%, and one death (2.38% of the population).
Conclusion: Chikungunya fever is a disease that can manifest differently according to age group. The diagnosis must be made early to mitigate possible injuries and complications.
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http://dx.doi.org/10.1016/j.jped.2025.01.010 | DOI Listing |
Cells
February 2025
Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str. 7, 97078 Würzburg, Germany.
Cellular metabolism must adapt rapidly to environmental alterations and adjust nutrient uptake. Low glucose availability activates the AMP-dependent kinase (AMPK) pathway. We demonstrate that activation of AMPK or the downstream Unc-51-like autophagy-activating kinase (ULK1) inhibits receptor-mediated endocytosis.
View Article and Find Full Text PDFMed Trop Sante Int
December 2024
Département de biologie et physiologie animales, Université de Yaoundé 1, Cameroun.
Objectives: The aim of this study was to identify chikungunya vectors and study their bioecology in order to contribute to the response to the 2020 epidemic in the cities of Abéché and Biltine in eastern Chad.
Materials And Methods: Immature stages of mosquitoes were collected and epidemic risk indices (Container index, House index and Breteau index) were calculated and compared using the Chi-square test. The collected larvae and nymphs were reared, and the resulting adults were morphologically identified using a dichotomous key.
J Pediatr (Rio J)
March 2025
Centro Universitário Faculdade de Medicina do ABC (FMABC), Programa de Pós-Graduação em Ciências da Saúde, Santo André, SP, Brazil.
Objective: To describe the clinical spectrum of pediatric and adolescent patients infected with Chikungunya.
Methods: Cross-sectional study with patients aged 0 to 17 years hospitalized with a Chikungunya Fever diagnosis in Ceará, in 2017. Data were collected on the clinical manifestations associated with the condition; significant differences were considered when p < 0.
J Infect Public Health
February 2025
Department of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan; Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo 693-8501, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan; DEJIMA Infectious Disease Research Alliance, Nagasaki University, Japan. Electronic address:
Background: Chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, causes significant morbidity characterized by acute febrile illness to chronic and permanent disability in some patients. Despite its potential for severe long-term effects, surveillance for CHIKV remains limited, especially in dengue-endemic region like Sri Lanka. To address the gap in surveillance, this study aimed to determine the prevalence of CHIKV among patients suspected of dengue fever during the 2017-2019 DENV outbreak in Sri Lanka.
View Article and Find Full Text PDFPLoS Negl Trop Dis
March 2025
Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China.
Background: Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is responsible for disease outbreaks worldwide. However, systematic knowledge of spatiotemporal distribution and risk patterns of CHIKV in mainland Europe remains unclear. Our aim was to decipher the epidemiological characteristics, diversity, and clinical manifestations of CHIKV.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!