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Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression.
Clin Transl Med
March 2025
Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Tumour-associated microbiota are integral components of the tumour microenvironment (TME). However, previous studies on intratumoral microbiota primarily rely on bulk tissue analysis, which may obscure their spatial distribution and localized effects. In this study, we applied in situ spatial-profiling technology to investigate the spatial distribution of intratumoral microbiota in breast cancer and their interactions with the local TME.
View Article and Find Full Text PDFFusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.
BMC Res Notes
March 2025
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.
Results: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included.
Periodontal pathogens as potential risk factors for systemic diseases: An overview.
Acta Microbiol Immunol Hung
March 2025
2Department of Cardiology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, India.
There is a plethora of evidence that suggests infection may either directly or indirectly trigger chronic inflammatory processes which may then act as a risk factor for diabetes mellitus and atherosclerosis. Inflammatory periodontal disease like periodontitis, is among the most prevalent oral infectious disease. It affects the tissues that support the teeth and has reportedly been linked to systemic conditions like diabetes mellitus and atherosclerosis.
View Article and Find Full Text PDFGut microbiota and integrins are known to contribute to colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that upregulated integrin α5 (ITGA5) in CRC in both human patients and murine models. Knocking down in CRC cells weakened the ability of to stimulate their malignant characteristics.
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