Introduction: Data on the utility of coagulation factor testing (INR, aPTT) in non-anticoagulated patients with low-risk trauma is limited. In this study, we describe the rate in which coagulation studies are ordered this population and report the frequency in which these tests were abnormal and resulted in intervention.

Methods: This was a multi-center retrospective observational study evaluating patients aged 65 years and older with low-risk mechanical falls not on chronic oral anticoagulation. If blood work was obtained, we documented the initial/highest INR and the initial/highest aPTT. Our primary outcome was the frequency of intervention due to abnormal coagulation studies, defined as (1) administration of vitamin K, FFP, PCC, or protamine and/or (2) admission/observation due to the abnormal coagulation study.

Results: A total of 1208 patients were included. The frequency in which an INR was obtained was 559 (46.3 %). The median value of the INR was 1.1 (range 0.9-1.6). There were 536 patients (44.4 %) who had aPTT drawn. The median value was 26.2 (range 20.1-43.4). There were no instances of our primary outcome (abnormal INR or aPTT that required intervention).

Conclusion: In this cohort of 1208 patients, approximately 45 % percent had coagulation studies ordered and nearly 95 % of these studies were normal. None of them were critically elevated, necessitating intervention. Our findings suggest that for patients similar to those in our study cohort, routine coagulation studies may have limited utility and are unlikely to result in changes in ED management.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2025.02.046DOI Listing

Publication Analysis

Top Keywords

coagulation studies
16
utility coagulation
8
coagulation factor
8
factor testing
8
low-risk mechanical
8
mechanical falls
8
inr aptt
8
studies ordered
8
primary outcome
8
abnormal coagulation
8

Similar Publications

Fictitious disorder by proxy (FDP) is characterized by an adult, often a parent, alleging or fabricating symptoms in a child to induce repeated diagnostic tests or treatments. This form of abuse is particularly serious and difficult to diagnose. Worldwide, it is estimated that 0.

View Article and Find Full Text PDF

Fluid management in hemorrhagic shock.

Curr Opin Anaesthesiol

March 2025

Department of Anesthesiology and Intensive Care Medicine, Trauma Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria.

Purpose Of Review: Fluid management in hemorrhagic shock is a controversial topic, and there are evolving clinical guidelines and evidence-based practice. This review aims to highlight the physiological aspects in the light of current evidence on which volume replacement solution to use.

Recent Findings: Current evidence and international guidelines are shifting from a liberal to a restrictive fluid resuscitation strategy, emphasizing the potential risks associated with aggressive fluid therapy.

View Article and Find Full Text PDF

Background: Amniotic fluid (AF) plays a key role in fetal development, yet the evolving composition of AF and its effects on hemostasis and thrombosis are poorly understood.

Objectives: To characterize the procoagulant properties of AF as a function of gestation in humans and nonhuman primates.

Methods: We analyzed the proteomes, lipidomes, and procoagulant properties of AF obtained by amniocentesis from rhesus macaque and human pregnancies at gestational age-matched time points.

View Article and Find Full Text PDF

Introduction: Data on the utility of coagulation factor testing (INR, aPTT) in non-anticoagulated patients with low-risk trauma is limited. In this study, we describe the rate in which coagulation studies are ordered this population and report the frequency in which these tests were abnormal and resulted in intervention.

Methods: This was a multi-center retrospective observational study evaluating patients aged 65 years and older with low-risk mechanical falls not on chronic oral anticoagulation.

View Article and Find Full Text PDF

Revealing the removal behavior of five neglected microplastics in coagulation-ultrafiltration processes: Insights from experiments and predictive modeling.

J Hazard Mater

March 2025

State Key Laboratory of Hydraulics and Mountain River Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, PR China; Yibin Institute of Industrial Technology, Sichuan University Yibin Park, Yibin 644000, PR China; Sichuan University-The Hong Kong Polytechnic University Institute for Disaster Management and Reconstruction, Sichuan University, Chengdu 610065, PR China. Electronic address:

Typical water treatment processes are essential for mitigating the risk of microplastic contamination in drinking water. The integration of experiments and machine learning offers a promising avenue to elucidate microplastic removal behavior, yet relevant studies are scarce. To address this gap, this study combined experimental and artificial neural network (ANN) modeling to explore the removal behavior and mechanisms of five neglected microplastics in typical coagulation-ultrafiltration processes.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!