Objectives: There is still no consensus regarding the indications of long-acting injectable antipsychotics (LAIs) in early psychosis (EP). This umbrella review synthesizes findings from systematic reviews and meta-analyses on the risk-benefit balance of LAIs in EP.
Methods: Eligible systematic reviews and meta-analyses on LAIs in EP were identified by a MEDLINE search from inception until June 2024. Data were synthesized narratively.
Results: Seven systematic reviews and four meta-analyses published from 2007 to 2024 were identified. They included 220 to 14,313 participants recruited in 58 primary unique randomized controlled trials or observational studies. All LAIs were considered in most reviews. Inclusion criteria and diagnoses differed widely across the selected reviews. The reviews and meta-analyses consistently showed a positive impact of LAIs on symptomatic outcome in people with EP, although there was no consensus on whether LAIs outperformed oral anti-psychotics (OAPs). Most reported a greater reduction of treatment discontinuation due to inefficacy or nonadherence with LAIs vs. OAPs, although meta-analyses found no difference between LAIs vs. OAPs regarding all-cause discontinuation. Findings regarding relapse prevention were inconclusive. Similar rates of metabolic adverse drug reaction and potentially lower rates of extrapyramidal symptoms were observed with LAIs vs. OAPs.
Conclusion: LAIs should be considered according to users' preferences and could be particularly useful for people with a poor medication adherence risk profile. Further high-quality observational studies in real-life prescribing conditions are needed to support robust recommendations for clinical practice regarding indications of LAIs in EP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.schres.2025.03.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety and recovery profile of patients after inhalational anaesthesia versus target-controlled or manual total intravenous anaesthesia: a systematic review and meta-analysis of randomised controlled trials.
Br J Anaesth
March 2025
Department of Surgical Interventional Sciences, McGill University Health Center, Montreal, QC, Canada; Department of Anesthesia, McGill University, Montreal, QC, Canada; Department of Surgery, McGill University, Montreal, QC, Canada. Electronic address:
Background: In the UK, total intravenous anaesthesia (TIVA) is used in 25% of general anaesthetics and is gaining traction because of its lower environmental impact and effectiveness in reducing postoperative nausea and vomiting (PONV). Although meta-analyses have compared TIVA and inhalational anaesthesia (IA), the optimal delivery method-manual infusion or target-controlled infusion (TCI)-remains underexplored. This review addresses this gap, leveraging the rapidly growing body of evidence to guide optimal anaesthetic practice.
View Article and Find Full Text PDFEffect of Home-based Virtual Reality Training on Upper Extremity Recovery in Patients with Stroke: Systematic Review.
J Med Internet Res
March 2025
Rehabilitation Lab of Mix Reality, Shenzhen Hospital, Southern Medical University, Shenzhen, CN.
Background: Stroke is a leading cause of long-term disability, often resulting in upper extremity dysfunction. Traditional rehabilitation methods often face challenges such as limited patient access to resources and lack of sustained motivation. Home-based virtual reality (VR) training is gaining traction as an innovative, sustainable and interactive alternative.
View Article and Find Full Text PDFChallenges and support needs among family caregivers involved in solid organ transplant care process: a scoping review protocol.
BMJ Open
March 2025
Department of Nursing Management, The First Affiliated Hospital of Guangzhou Medical University National Clinical Research Center for Respiratory Diseases, Guangzhou, Guangdong, China
Introduction: Family caregivers play an indispensable role in the care of solid organ transplant patients, undertaking a wide range of tasks from basic daily care to complex medical management. However, these responsibilities come with substantial challenges, placing additional strain on caregivers who bear significant physical, emotional, financial and social burdens, along with numerous unmet support needs. Currently, the exploration of challenges and support needs among family caregivers in the caregiving process is limited to primary research, lacking a synthesised and comprehensive understanding of the issues.
View Article and Find Full Text PDFAccess and use of general and mental health services before and during the COVID-19 pandemic: a systematic review and meta-analysis.
BMJ Open
March 2025
Institute of Public Health, Universita della Svizzera italiana, Lugano, Ticino, Switzerland.
Objectives: To quantify access to health services during the COVID-19 pandemic and measure the change in use between the prepandemic and the pandemic periods in a population with assessment of psychological distress or diagnosis of mental disorders.
Data Sources: We developed and piloted a search syntax and adapted it to enter the following databases from 1 January 2020 to 31 March 2023: PubMed/MEDLINE, PsycINFO, Web of Science, Epistemonikos and the WHO International Clinical Trials Registry Platform. We reran the searches from the end of the original search to 3 December 2024.
Factors associated with prehospital and in-hospital delays in acute ischaemic stroke care in Indonesia: a systematic review.
BMJ Open
March 2025
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
Objectives: This systematic review examines prehospital and in-hospital delays in acute stroke care in Indonesia.
Design: Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Data Sources: We conducted a thorough search across 11 databases, ClinicalTrials.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!