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The mechanisms of resistance, epidemiological characteristics, and molecular evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae.
Lab Med
March 2025
Department of Clinical Laboratory, People's Hospital of Dayi County, Chengdu Sichuan, China.
Introduction: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a highly pathogenic, drug-resistant, and transmissible "superbug" that causes infections in hospitals and communities. Because of the lack of effective antimicrobial treatment options, morbidity and mortality from CR-hvKP infections have increased dramatically, and outbreaks and the rapid spread of CR-hvKP in hospitals have become a major global public health challenge.
Methods: The mechanisms of molecular evolution in CR-hvKP include the acquisition of a hypervirulent plasmid encoding a virulence gene by carbapenemase-producing K pneumoniae, the horizontal transfer of plasmids carrying carbapenem resistance genes to hvKP, and the acquisition of fusion plasmids carrying both carbapenem resistance genes and hypervirulent genes by classic K pneumoniae.
The emergence of highly resistant and hypervirulent Escherichia coli ST405 clone in a tertiary hospital over 8 years.
Emerg Microbes Infect
March 2025
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
The emergence of carbapenem-resistant (CREC) poses crucial challenges in clinical management, requiring continuous monitoring to inform control and treatment strategies. This study aimed to investigate the genomic and epidemiological characteristics of CREC isolates obtained from a tertiary hospital in China between 2015 and 2022. Next-generation sequencing was used for genomic profiling, and clinical data from patients were integrated into the analysis.
View Article and Find Full Text PDFIncreasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023.
Commun Med (Lond)
March 2025
Department of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Background: Development of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a severe challenge to public health. Here we aimed to perform a retrospective study of prevalence and molecular characteristics of polymyxin-resistant CRKP strains.
Methods: 4455 clinical CRKP strains from 18 provinces in China during 2000 to 2023 were collected.
Carbapenem-resistant hypervirulent Klebsiella pneumoniae: where is it headed in the tug-of-war between virulence and resistance?
EBioMedicine
March 2025
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China; Institute of Medical Technology, Peking University Health Science Center, Beijing, China. Electronic address:
Mobile genetic elements encoding antibiotic resistance genes and virulence genes in : important pathways for the acquisition of virulence and resistance.
Front Microbiol
February 2025
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
is an opportunistic pathogen primarily associated with nosocomial infections, characterized by a propensity for multi-drug resistance and the potential evolution into hypervirulent strains. Based on its phenotypic and genotypic characteristics, can be classified into two types: classical (cKP) and hypervirulent (hvKP). The spread of mobile genetic elements (MGEs) in has led to the emergence of carbapenem-resistant (CRKP) and carbapenem-resistant hypervirulent (CR-hvKP).
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