The use of natural products for therapeutic purposes is a common practice since the beginning of time, as it was already known that they contained biological components beneficial to health, which also justifies the growing demand for products made from Amazonian raw materials. The accessibility to information and an aggressive marketing favored the consumption of these products globally. However, the legislation in different countries on how to obtain plant raw materials, process them and subsequently sell them can leave gaps and doubts leading the consumer to make mistakes. This may interfere with an efficient inspection by official control agencies, also leading to inappropriate consumption. This exploratory study investigated chemical properties of natural products from Amazonian sources sold on the Web in several countries, as well as the prevailing norms, in order to contribute to the safety of consumption for this type of products.
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http://dx.doi.org/10.1016/j.foodchem.2025.143656 | DOI Listing |
Am J Public Health
April 2025
Kristen M. Brown, Brigette Courtot, Zara Porter, and Sofia Hinojosa are with the Health Policy Center, Urban Institute, Washington, DC.
The Centers for Disease Control and Prevention's Partnering for Vaccine Equity program was developed during the COVID-19 public health emergency to fund more than 500 community-based organizations working to improve vaccine equity. Organizations were supported by a virtual learning community where members received tailored learning content, peer-to-peer learning opportunities, and resources that facilitated deployment of vaccine-related programming during a dynamic pandemic. Process evaluation metrics indicate successful implementation of the learning community.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Pharmacology and Therapeutics, Usmanu Danfodiyo University, Sokoto, Nigeria.
Background: COVID-19 still poses a major public health challenge worldwide and vaccination remains one of the major interventions to control the disease. Different types of vaccines approved by the World Health Organization (WHO) are currently in use across the world to protect against the disease. This study assessed the prevalence and pattern of adverse events following immunization (AEFI) after receiving COVID-19 vaccine (the Oxford-AstraZeneca vaccine) among the adult population in Sokoto metropolis, North-west, Nigeria.
View Article and Find Full Text PDFOrg Lett
March 2025
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
2-Quinolones represent a versatile class of compounds that are prevalent in natural and medicinally relevant molecules. Here we report a new approach to the selective formation of these structures. By gold catalysis, a range of benzaldehyde-tethered ynamides reacted with anilines, leading to 4-amino-3,4-dihydro-2-quinolones with high efficiency and excellent diastereoselectivity in dichloromethane.
View Article and Find Full Text PDFOrg Lett
March 2025
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi 38677, United States.
Astracondensatol D (), a pentacyclic triterpenoid featuring an uncommon 6/6/5/6-fused ring system, along with its precursor astracondensatol E (), and two simplified 20(27)-octanorcycloastragenol derivatives ( and ) were isolated from for the first time. Classical NMR spectroscopic data, integrated with NMR and DP4+ calculations, unambiguously determined their absolute stereostructures. X-ray crystallography provided independent confirmation of the structure of compound .
View Article and Find Full Text PDFJ Immunol
January 2025
Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from human, swine, and avian influenza A viruses. The lipid nanoparticle (LNP)-encapsulated 5xM2e mRNA vaccine was immunogenic, eliciting high levels of M2e-specific IgG antibodies, IFN-γ+ T cells, T follicular helper cells, germinal center phenotypic B cells, and plasma cells.
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