Background: The effect of cultural differences in neurodegenerative diseases is not well understood. We aimed to investigate the cognitive profiles of English- and Spanish-speaking individuals with primary progressive aphasia (PPA).
Methodology: A comparative cross-sectional study was conducted with 461 participants: 215 participants from Australia and 246 from Spain. The Australian cohort included 131 PPA patients: 37 nonfluent PPA (nfvPPA), 49 semantic PPA (svPPA), 45 logopenic (lvPPA) and 84 healthy controls (HC); the Spanish cohort had 162 PPA: 64 nfvPPA, 31 vsPPA, 67 lvPPA, and 84 HC. All participants completed the ACE-III and other tests assessing verbal working memory, attention/executive functioning, visuospatial constructional abilities and episodic memory. A subgroup of participants underwent structural brain MRI. Cognitive performance and neuroimaging were compared between groups.
Results: The most salient differences between each variant and HC were similar in the Australian and Spanish cohort. However, the Spanish cohort scored lower than the Australian cohort in most cognitive tests evaluated (ACE-III total, attention, memory and visuospatial in nfvPPA; attention, memory, and visuospatial in svPPA; and memory, language, and visuospatial in lvPPA). Differences were particularly pronounced in the visuospatial subdomain among nonfluent variant PPA. Cortical thickness analysis showed the expected regional atrophy in each PPA variant, but with no greater atrophy in the Spanish cohort.
Conclusion: These findings revealed an impairment in other cognitive domains beyond language in PPA. However, Spanish patients exhibited more generalized cognitive involvement despite similar demographic and neuroimaging profiles, suggesting that cultural and resilience factors may influence PPA presentations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jns.2025.123446 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study.
JMIR Form Res
March 2025
Program in Digital Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Background: Screening for cognitive impairment in primary care is important, yet primary care physicians (PCPs) report conducting routine cognitive assessments for less than half of patients older than 60 years of age. Linus Health's Core Cognitive Evaluation (CCE), a tablet-based digital cognitive assessment, has been used for the detection of cognitive impairment, but its application in primary care is not yet studied.
Objective: This study aimed to explore the integration of CCE implementation in a primary care setting.
Objectives: To assess if implementing interventions to effectively manage preoperative chronic moderate to severe shoulder pain in patients undergoing rotator cuff repair (RCR) can improve shoulder surgery outcomes.
Methods: A systematic review was conducted following the PRISMA and SIGN guidelines. Randomized clinical trials (RCT), metanalysis, systematic revisions and cohort studies in Spanish/English, published within the last 10 years, evaluating interventions to control preoperative chronic moderate to severe shoulder pain in patients undergoing RCR and their impact in postoperative shoulder outcomes were included.
Highlights from the breakout session: diagnosis and classification of vasculitis.
Rheumatology (Oxford)
March 2025
Rheumatology Department, Health New Zealand, Auckland, New Zealand.
The session on 'Diagnosis and Classification of Vasculitis' featured six oral presentations covering various aspects of vasculitis diagnosis and classification. The application of the Ankara criteria for IgA vasculitis in adults was evaluated, finding that while the criteria showed good sensitivity, their specificity was insufficient, suggesting the need for refinement. A clustering approach to classifying ANCA-associated vasculitis (AAV) identified five distinct clusters, which improved prediction of disease outcomes.
View Article and Find Full Text PDFImproving Postpartum Follow-Up with Telehealth: Did the Pandemic Nudge Us in a Better Direction?
Dela J Public Health
December 2024
Department of Family Medicine, Warren Alpert Medical School at Brown University.
Objective: To investigate if a telehealth option as the initial postpartum visit would increase postpartum visit attendance.
Methods: This was a retrospective cohort study of women receiving prenatal care through a federally qualified health center, Westside Family Health in Delaware, comparing attendance at a postpartum visit before telehealth was an option (2018) versus after the onset of the pandemic (2021). Representative random samples were taken from one year of deliveries pre- and post-implementation of the telehealth visit option.
Long-term persistence with secukinumab in patients with moderate-to-severe psoriasis.
Farm Hosp
March 2025
Servicio de Farmacia, Hospital de Alzira, Valencia, España.
Objective: The aim of this his study was to evaluate the real-world persistence, effectiveness, and safety of secukinumab in adult patients with moderate-to-severe psoriasis in two different hospitals.
Methods: Retrospective cohort study that used registries and medical records from 2 different hospitals (February 2015 to March 2024). Adults with moderate-to-severe psoriasis who initiated secukinumab treatment were identified and followed-up until March 2024, or disenrollment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!