Driver drowsiness significantly contributes to road accidents worldwide, and timely prediction of driver reaction time is crucial for developing effective advanced driver assistance systems. In this paper, we present an EEG-based prediction framework that investigates the impact of different pre-stimulus time windows, frequency band combinations, and channel groups on driver reaction time estimation using data from a 90-minute sustained attention driving task. Our systematic evaluation using a publicly available dataset of 24 drivers reveals that a 2-second pre-stimulus window yields the lowest prediction error. Notably, our proposed 1D Convolutional Neural Network (CNN) approach reduces the Mean Absolute Error (MAE) by nearly 30\% (from 0.51 sec to 0.36 sec for the alpha band) compared to classical machine learning models. Moreover, while individual frequency bands (e.g., alpha and theta) outperform combined band approaches, most spatial channel groups deliver similar performance to the full 32-channel configuration-with the exception of frontal channels. These improvements underscore the potential for real-world applications in reducing road accidents by enabling timely interventions based on predictive analytics.
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http://dx.doi.org/10.1088/2057-1976/adbf25 | DOI Listing |
Am J Chin Med
March 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007, P. R. China.
Liver cirrhosis is a critical stage in the progression of various chronic liver diseases, often leading to severe complications such as ascites, hepatic encephalopathy, and a high mortality rate, and it thus poses a serious threat to patient life. The activation of hepatic stellate cells is a central driver of disease progression. Cellular autophagy, a lysosome-mediated degradation process, plays a key role in maintaining cellular function and dynamic homeostasis.
View Article and Find Full Text PDFBiomed Phys Eng Express
March 2025
Faculty of Engineering and Computing, Dublin City University, Dublin 9, Dublin, IRELAND.
Driver drowsiness significantly contributes to road accidents worldwide, and timely prediction of driver reaction time is crucial for developing effective advanced driver assistance systems. In this paper, we present an EEG-based prediction framework that investigates the impact of different pre-stimulus time windows, frequency band combinations, and channel groups on driver reaction time estimation using data from a 90-minute sustained attention driving task. Our systematic evaluation using a publicly available dataset of 24 drivers reveals that a 2-second pre-stimulus window yields the lowest prediction error.
View Article and Find Full Text PDFJ Environ Manage
March 2025
Department of Mechanical Engineering, 10-241, Donadeo Innovation Center for Engineering, Advanced Water Research Lab (AWRL), University of Alberta, Edmonton, AB, T6G 1H9, Canada. Electronic address:
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that pose significant toxicity risks to humans and ecosystems. Traditional advanced oxidation processes using boron-doped diamond (BDD) anodes degrade PFAS in wastewater effectively but suffer from slow kinetics and high energy costs, limiting commercial application. This study introduces a hybrid process combining cathodic electro-Fenton (EF), anodic oxidation via a BDD anode, and membrane distillation (MD) to improve perfluorooctanoate (PFOA) degradation efficiency and reduce energy use.
View Article and Find Full Text PDFEndemic Burkitt lymphoma (eBL) is one of the most prevalent cancer in children in sub-Saharan Africa, and while prior studies have found that Epstein-Barr virus (EBV) type and variation may alter the tumor driver genes necessary for tumor survival, the precise relationship between EBV variation and EBV-associated tumorigenesis remains unclear due to lack of scalable, cost-effective, viral whole-genome sequencing from tumor samples. This study introduces a rapid and cost-effective method of enriching, sequencing, and assembling accurate EBV genomes in BL tumor cell lines through a combination of selective whole genome amplification (sWGA) and subsequent 2-tube multiplex polymerase chain reaction along with long-read sequencing with a portable sequencer. The method was optimized across a range of parameters to yield a high percentage of EBV reads and sufficient coverage across the EBV genome except for large repeat regions.
View Article and Find Full Text PDFExplor Target Antitumor Ther
February 2025
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran 16635148, Iran.
Glioblastoma, an aggressive and lethal brain tumor, presents enormous clinical challenges, including molecular heterogeneity, high recurrence rates, resistance to conventional therapies, and limited therapeutic penetration across the blood-brain barrier. The glioblastoma microenvironment, characterized by a dynamic interplay of cellular and non-cellular components, is a key driver of tumor growth and therapeutic resistance. Neuroinflammatory cytokines, particularly interleukins and tumor necrosis factor-alpha, play pivotal roles in this microenvironment, contributing to tumor progression and immune evasion.
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