Background: Stroke is a prevalent neurological disease with high morbidity and disability. Single-task walking training has limitations, and dual-task walking training has emerged. Yet, research on the relative effectiveness of dual- and single-task training for stroke patients' walking function is inconclusive. This study aims to systematically compare the efficacy of dual-task with single-task training interventions on improving walking function among stroke survivors.
Methods: A comprehensive search of electronic databases was conducted to identify randomized controlled trials investigating the application of dual-task training on walking function in stroke patients. Two reviewers independently screened the references, selected relevant studies, extracted data, and assessed the risk of bias. The primary outcome measures related to walking function included step speed, step length, stride length, step frequency, Berg balance scale (BBS), and timed up and go (TUG) test. The Cochrane risk of bias tool was used for methodological quality assessment of the included literature. Statistical analysis was performed using RevMan 5.4 software. Furthermore, the quality of evidence of the outcome measures was evaluated using the GRADEPro software.
Results: A total of 17 studies were enrolled in this systematic review and meta-analysis. The results revealed that dual-task training exhibited significantly superior efficacy compared to single-task training in enhancing step speed, step length, stride length, step frequency, and BBS score (P < .05). However, no significant difference was observed in the TUG test (P = .100).
Conclusion: Compared with traditional single-task training, dual-task training could be more effective in improving walking function among stroke patients, especially with regard to temporal and spatial parameters such as step length and speed, stride frequency and BBS score, but the effect on enhancing TUG test still remains unclear. These findings would help clinicians to formulate a more rational stroke rehabilitation strategy.
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http://dx.doi.org/10.1097/MD.0000000000041776 | DOI Listing |
PLoS One
March 2025
Faculty of Education, Mie University, Mie, Japan.
This study is the first in Japan to prospectively examine the relationship between walking to and from school and physical activity in primary school children. A total of 76 participants completed baseline and follow-up assessments, and their mean age was 9.6 ± 1.
View Article and Find Full Text PDFSci Robot
March 2025
NeuroX Institute and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. Here, we developed an implantable spinal cord neuroprosthesis operating in a closed loop to promote robust activity during walking and cycling assisted by robotic devices.
View Article and Find Full Text PDFJ Pediatr Orthop
March 2025
Shriners Children's Portland, Portland, OR.
Background: Toe walking is prevalent among children, affecting 5% to 24% of the pediatric population. Clinicians rely on parental reports of frequency of toe walking to guide clinical decision making and outcomes assessment. However, recall accuracy and differing environments challenge the reliability of parental reports.
View Article and Find Full Text PDFAnal Chem
March 2025
Shandong Key Laboratory of Biophysics, Institute of Biophysics, Institute of Rural Revitalization, School of Pharmacy, Dezhou University, 253023 Dezhou, China.
Peripheral blood circulating tumor DNA (ctDNA) is a crucial liquid biopsy biomarker that correlates overall systemic tumor burden with malignant progression. However, identifying multiple single nucleotide polymorphisms (SNPs) in ctDNA presents significant challenges. In this study, we developed a rolling circle amplification (RCA)-supported multipedal DNA walker integrated with toehold-mediated strand displacement (TSDR) to facilitate the detection of ctDNA SNPs.
View Article and Find Full Text PDFAsia Pac J Public Health
March 2025
Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan.
In 2020, the coronavirus disease 2019 (COVID-19) pandemic altered lifestyles dramatically. We previously reported that the physical function of walk-in rehabilitation users in Japan worsened after the state of emergency declaration and continued to worsen until the end of 2020. However, whether physical function continued to worsen during the prolonged pandemic period remains unclear.
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