This study aims to investigate the causes and risk factors of recurrence within 6 months after transcatheter bronchial artery embolization for massive hemoptysis in pulmonary tuberculosis. A retrospective observational study was conducted on the clinical data of 237 patients with pulmonary tuberculosis and massive hemoptysis who relapsed within 6 months after bronchial artery embolization. Univariate analysis was first conducted to screen for risk factors with statistical significance, and then multivariate logistic regression analysis was performed to infer the risk factors that might lead to the recurrence of hemoptysis. Twenty-four relapsed within 6 months after the operation, and the recurrence rate was 10.1% (24/237). Logistic multivariate regression analysis revealed that 6 risk factors were included in the regression model. The strength of the effect was as follows: postoperative lesion progression (odds ratio [OR] = 4.429, 95% confidence interval [CI]: 2.833-7.283), number of feeding arteries (OR = 2.592, 95% CI: 1.457-4.741), combined bronchiectasis (OR = 2.324, 95% CI: 1.912-5.682), presence of cavitation (OR = 1.933, 95% CI: 1.406-2.451), systemic-to-pulmonary shunt (OR = 1.596, 95% CI: 1.044-2.409), and lesion lobe distribution (OR = 1.056, 95% CI: 1.006-1.128). Postoperative lesion progression, a large number of feeding arteries, combined bronchiectasis, presence of cavities, existence of a systemic-to-pulmonary shunt, and wide lesion distribution are independent risk factors for postoperative recurrence.
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http://dx.doi.org/10.1097/MD.0000000000041734 | DOI Listing |
AIDS Care
March 2025
Faculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil.
In Brazil, pre-exposure prophylaxis (PrEP) is freely available to individuals at high risk of HIV infection. However, knowledge and perception of PrEP can act as barriers to its access and use. This study evaluated PrEP knowledge and perception among healthcare workers in the Unified Health System in a Brazilian capital.
View Article and Find Full Text PDFCancer Discov
March 2025
University of California, San Francisco, San Francisco, CA, United States.
Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. Here, we carried out whole genome sequencing to demonstrate that initiated cells with thousands of mutagen-induced mutations can persist for long periods and are not removed by cell competition or by immune intervention, thus mimicking the persistence of cells with cancer driver mutations in normal human tissues.
View Article and Find Full Text PDFAIDS Care
March 2025
Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Methamphetamine use among sexual minority men (SMM) has been associated with poor ART adherence, and reduced initiation and adherence to PrEP. From May 2021 to May 2023, 226 SMM were enrolled in , a culturally responsive smartphone application to reduce methamphetamine use and improve sexual health. Using a status-neutral approach, an ordinal variable reflected participants' placement on the HIV Prevention/Care Continuum, from HIV-positive, not taking ART, to HIV-negative, currently taking PrEP.
View Article and Find Full Text PDFClin Transplant
March 2025
Division of Cardiac Surgery, CardioVascular Center, Tufts Medical Center, Boston, Massachusetts, USA.
Background: This study aims to analyze the patient characteristics, clinical outcomes, and contemporary trends concerning type A aortic dissection (TAAD) in previous recipients of abdominal solid organ transplantation (ASOT) in the United States.
Methods: The National Inpatient Sample was queried to identify all patients aged ≥18 with TAAD and a history of ASOT (TAAD-ASOT) between 2002 and 2015Q3 using ICD-9 diagnosis and procedure codes. Baseline characteristics and in-hospital outcomes were compared between TAAD-ASOT patients and TAAD patients without a history of ASOT (TAAD-non-ASOT).
Genetic factors contribute to the development of metabolic syndrome and subsequent arterial hypertension (AH). The study of the T786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene in arterial hypertension is important as its correlation with adipokine imbalance is a novelty area to find associations between hypertension development, obesity, and heredity. The purpose of the current study was to investigate serum adipokines levels, depending on the T786C polymorphism of the eNOS in patients with arterial hypertension.
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