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Impact of Aromatase and ESR1 expression in SAT on insulin resistance and T2D in obese men.
J Clin Endocrinol Metab
March 2025
Biochemistry Section, Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha, Avda. Camilo José Cela 10, 13071 Ciudad Real, Spain.
Discovery of novel benzoxazole analogues as potential anticancer agent selectively targeting aromatase.
Bioorg Med Chem
February 2025
Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
Estrogen play an important role in the development of breast cancer in menopausal women. Aromatase, an enzyme that catalyses the last step in the production of estrogen, has been identified as a promising target for clinical development. In the present investigation, novel 2-substituted benzoxazoles were synthesized and evaluated for inhibition against aromatase.
View Article and Find Full Text PDFOvulation induction in anovulatory PCOS women.
Minerva Obstet Gynecol
March 2025
Unit of Obstetrics and Gynecology, Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Modena, Italy -
Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder characterized by hyperandrogenism, chronic anovulation, and polycystic ovarian morphology, affecting 6-10% of women during their reproductive years. It is a leading cause of female infertility, impacting up to 40% of cases. First described in 1935, PCOS manifests with various clinical features, including hirsutism, amenorrhea, and metabolic disturbances.
View Article and Find Full Text PDFLepidium Sativum Extract Alleviates Reproductive and Developmental Toxicity in Polycystic Ovary Syndrome Induced by Letrozole and High-Fat Diet in Rats.
Reprod Sci
March 2025
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovarian morphology, leading to infertility and an increased risk of metabolic dysfunction. This study investigated the protective effects of Lepidium sativum seed extract (LSSE) on fertility and pregnancy outcomes in a rat model of PCOS induced by letrozole and a high-fat diet (HFD) (68% regular rat food pellets, 6% maize oil, 20% milk powder, and 6% ghee). PCOS was induced by oral administration of letrozole, an aromatase inhibitor, (1 mg/kg in 2% DMSO) along with an HFD for four weeks and the results were compared to the metformin antidiabetic agent.
View Article and Find Full Text PDFHealth-related quality of life in patients with HR+/HER2- early breast cancer treated with ribociclib plus a nonsteroidal aromatase inhibitor: results from the NATALEE trial.
Clin Cancer Res
February 2025
The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Purpose: The phase 3 NATALEE trial reported a statistically significant invasive disease-free survival benefit with ribociclib plus nonsteroidal aromatase inhibitor (NSAI) versus an NSAI alone in stage II/III hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer (EBC). Here we report health-related quality of life (HRQOL) data from NATALEE.
Patients And Methods: Patients were randomized to receive ribociclib plus NSAI or NSAI alone.
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