Given their hydrophilic nature, hydrogels have shown great potential as wound dressing materials. However, traditional hydrogel dressing materials are static and do not adapt to dynamic wound environments, which in turn limits their wound healing efficacy. Introducing dynamic covalent chemistries can be an effective strategy to improve hydrogel properties for effective wound healing, such as shape adaptability, stimuli responsiveness, self-healing capability, and antibacterial properties. We discuss the properties and chemistries of dynamic covalent bonds for wound healing. We critically analyze the advances of dynamic covalent hydrogels for wound healing and further propose new dynamic covalent chemistries for wound healing.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1146/annurev-chembioeng-082323-093537 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Poly(vinyl alcohol)/Polycaprolactone Nanofiber Enriched with Lichenysin against Multidrug-Resistance Bacterial Infection in Wound Healing: In Vitro Studies and In Vivo Evaluation in Wistar Rats.
ACS Appl Bio Mater
March 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow 226025, India.
Multidrug resistance (MDR) infectious wounds are a major concern due to drug resistance, leading to increased patient morbidity. Lichenysin (LCN), a lipopeptide and biosurfactant obtained from certain strains of , has demonstrated an excellent antimicrobial property. The present study focuses on the fabrication and comprehensive evaluation of LCN-incorporated poly(vinyl alcohol) (PVA)/polycaprolactone (PCL)-based nanofiber scaffolds using an electrospinning technique as a potential wound healing biomaterial for the treatment of MDR infectious wounds in diabetic rats.
View Article and Find Full Text PDFBlack raspberry seed oil - Chemical composition, antioxidant /antimicrobial activities and in vitro wound-healing potential.
Fitoterapia
March 2025
Institute for Medicinal Plants Research "Dr. Josif Pančić", 11000 Belgrade, Serbia.
This study aimed to perform chemical characterization of black raspberry seed oil (Rubus occidentalis L., Rosaceae) from Serbia in terms of fatty acids and tocols composition, total carotenoid content, as well as to investigate its antioxidant/antimicrobial activities and in vitro wound-healing potential. GC/MS analysis revealed that linoleic (39.
View Article and Find Full Text PDFExploring the potential of incorporating ZIF-67 into electrospun poly (vinyl alcohol)/chitosan nanofibrous mats for wound healing.
Int J Biol Macromol
March 2025
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
The current research emphasis is on the development of wound dressings that can inhibit bacterial infections and facilitate the treatment of complex wound healing processes. In this study, nanofibrous mats of polyvinyl alcohol/chitosan/ZIF-67(PVA/Cs/ZIF-67) were prepared using an electrospinning technique, to investigate their antibacterial and regenerative properties in a rat model of full-thickness skin wounds. ZIF-67 nanoparticles, with an average size of approximately 373.
View Article and Find Full Text PDFAdvancements, functionalization techniques, and multifunctional applications in biomedical and industrial fields of electrospun pectin nanofibers: A review.
Int J Biol Macromol
March 2025
Department of Orthopedics, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China. Electronic address:
Electrospun pectin nanofibers have emerged as a transformative advancement in biomaterials, offering remarkable potential across diverse biomedical and industrial applications. This review explores the synthesis, optimization, and versatile applications of electrospun pectin nanofibers, highlighting their unique properties, including biocompatibility, biodegradability, and adaptability for functionalization. Pectin's structural diversity, coupled with its ability to form hydrogels and interact with biological systems, makes it a promising candidate for wound healing, drug delivery, tissue engineering, and smart packaging.
View Article and Find Full Text PDFThe novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.
J Pharmacol Exp Ther
February 2025
Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Pulmonary fibrosis encompasses different chronic interstitial lung diseases, and the predominant form, idiopathic pulmonary fibrosis, remains to have a poor prognosis despite 2 approved therapies. Although the exact pathobiological mechanisms are still incompletely understood, epithelial injury and aberrant wound healing responses contribute to the gradual change in lung architecture and functional impairment. Lysophosphatidic acid (LPA)-induced lysophosphatidic receptor 1 (LPA1) signaling was proposed to be a driver of lung fibrosis, and LPA1 antagonists have shown promising antifibrotic profiles in early clinical development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!