This study evaluated the influence of applied pressure on the shear bond strength (SBS) between commercial 3Y-TZP zirconia and self-adhesive resin cement. Five test groups were created, each subjected to different applied pressures: 195.15, 97.47, 48.74, 9.75, and 0.20 kPa. A piston-type shear device was used to assess the effect of these pressures on cement layer thickness and SBS. The results demonstrated that the highest applied pressure (195.15 kPa) produced the thinnest cement layers (36.60 ± 1.67 μm) and the highest SBS values (58.8 ± 1.6 MPa), whereas the lower applied pressure (0.20 kPa) resulted in the thickest cement layers (73.20 ± 1.64 μm) and significantly lower SBS (30.8 ± 2.0 MPa). Regression analysis confirmed a strong correlation (R = 0.82, p < 0.05) between cement thickness and SBS, indicating that cement thickness is a critical factor influencing adhesion. These findings highlight the importance of controlling applied pressure during cementation to optimize bonding performance. Standardizing pressure application through calibrated pressure devices may improve the durability of zirconia-based restorations and minimize variability during the cementation process.
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http://dx.doi.org/10.1002/jbm.b.35563 | DOI Listing |
J Med Internet Res
March 2025
Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: Acceptance and commitment therapy provides a psychobehavioral framework feasible for digital and hybrid weight loss interventions. In face-to-face studies, group-based interventions yield more favorable outcomes than individual interventions, but the effect of the intervention form has not been studied in combination with eHealth.
Objective: This study investigated whether a minimal, 3-session group or individual enhancement could provide additional benefits compared to an eHealth-only intervention when assessing weight, body composition, and laboratory metrics in a sample of occupational health patients with obesity.
Drug Deliv Transl Res
March 2025
Regenerative Medicine & Cellular Therapies Division, School of Pharmacy, The University of Nottingham Biodiscovery Institute (BDI), University of Nottingham, Nottingham, NG7 2RD, UK.
Topically applied therapies must not only be effective at the molecular level but also efficiently access the target site which can be on milli/centimetre-scales. This bottleneck is particularly inhibitory for peptide and nucleic acid macromolecule drug delivery strategies, especially when aiming to target wounded, infected, and poorly perfused tissues of significant volume and geometry. Methods to drive fluid-flow or to enhance physical distribution of such formulations after local administration in accessible tissues (skin, eye, intestine) would be transformative in realizing the potential of such therapeutics.
View Article and Find Full Text PDFAdv Mater
March 2025
Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
Compression strongly degrades the electrical conductivity of the liquid-metal-based circuits because the liquid state is prone to be squashed. Here, a new compressible and stretchable biphasic liquid-solid self-healing circuit is proposed by filling GalnSn-BilnSn biphasic metal into micropillar-embedded channels. The underlying BilnSn solid alloy layer serves as a compression resistance layer, while the upper GalnSn liquid metal layer enables the real-time filling of the cracks in the solid layer under large deformations, resulting in autonomous self-healing and maintenance of conductivity under both stretching and compression.
View Article and Find Full Text PDFJ Glaucoma
March 2025
Department of Ophthalmology, Saarland University Medical Centre, Homburg/ Saar, Germany.
Prcis: Transscleral cyclophotocoagulation significantly reduces intraocular pressure and antiglaucomatous medication use post-penetrating keratoplasty, with low hypotony risk, particularly if delayed. Safe reintervention is feasible for intraocular pressure recurrence.
Purpose: Transscleral cyclophotocoagulation (TSCPC) is an established procedure for lowering intraocular pressure (IOP).
Biotechnol Prog
March 2025
Downstream Process Development (DSPD), WuXi Biologics, Shanghai, China.
In the downstream processing of antibody-based therapeutics, ultrafiltration/diafiltration (UF/DF) is commonly applied for concentration and buffer exchange in the final formulation. For a given molecule, various factors such as membrane type, feed flux, and transmembrane pressure (TMP) can significantly influence the performance of UF/DF, impacting yield, buffer exchange efficiency, and product quality. Conventional membrane pore size selection is based on product molecular weight to ensure high retention.
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