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Intraventricular injection of eravacycline in the treatment of carbapenem-resistant Acinetobacter baumannii meningitis: a case report.
J Antimicrob Chemother
March 2025
Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, People's Republic of China.
Histopathological and functional Characterization of a neonatal mouse model of intraventricular hemorrhage.
Neuroscience
March 2025
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, United States; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address:
Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is a major neurological problem of premature infants that leads to white matter injury and posthemorrhagic hydrocephalus. There is no optimal treatment for IVH-induced complications. Several animal models of IVH have been developed, but they have significant limitations.
View Article and Find Full Text PDFVirtual Post Mortem in Fetuses and Newborns for the Verification of Congenital Heart Malformations.
Pediatr Cardiol
March 2025
Department of Pediatric Cardiology, The Edmond J. Safra International Congenital Heart Center, Sheba Medical Center, Ramat Gan, Israel.
Post-mortem examinations of fetuses and newborns with congenital anomalies pose significant challenges, especially in cases of induced termination of pregnancy. To address this, we explored the use of virtual post-mortem examination (VPM) via computed tomography angiography (CTA) as a potential alternative. The study was conducted at Sheba Medical Center from January 2013 to June 2019.
View Article and Find Full Text PDFImpaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus.
Front Mol Neurosci
February 2025
Department of Neurology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea.
The cerebrospinal fluid (CSF) not only protects the brain but also maintains homeostasis by removing metabolic waste produced by brain activity. This study hypothesizes that chronic CSF circulatory dysfunction, such as chronic hydrocephalus or normal pressure hydrocephalus (NPH), may be a critical condition in neurodegenerative diseases associated with metabolic waste accumulation. To investigate the CSF circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus induced by kaolin injection, we performed time-dependent evaluations of intraparenchymal injection of tracers as well as intraventricular injection of Evans blue.
View Article and Find Full Text PDFSafety of Indocyanine Green Microdosing for Clinical Imaging of CSF Ventricular Dynamics and Extracranial Outflow.
J Neuroimaging
March 2025
Department of Pediatric Surgery, McGovern School of Medicine, The University of Texas Health Science Center, Houston, Texas, USA.
Background And Purpose: Intravenous administration of indocyanine green (ICG) has been approved in brain surgeries for decades, yet concerns about neurotoxicity prevent its direct administration into the cerebrospinal fluid (CSF). Armed with prior animal studies demonstrating the feasibility of using ICG microdosing into the CSF, we sought to evaluate its nonclinical safety profile and obtain surrogate measures in adults prior to its use in human neonates.
Methods: Evaluation of ICG toxicity was conducted in mixed primary CNS cell cultures and in an extended safety study of juvenile rat pups deploying intraventricular injections of saline (as control) or ICG.
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