The inherent unpredictability within the low-carbon integrated supply chain logistics network complicates its management. This paper endeavours to address the challenge of designing a low-carbon logistics network within a context of uncertainty and with consideration of low-carbon policies. It also endeavours to identify locations of facilities and appropriate transportation routes between nodes. Robust optimisation and fuzzy programming techniques are employed to examine the various attributes of the network. In addition, the strategic planning model of a multi-level forward/reverse integration logistics network is examined, with the aims of cost minimisation and emission reduction. Extensive computational simulations substantiate the efficacy of the proposed robust fuzzy programming model. Moreover, analytical results indicate the rationality and applicability of the decisions suggested by the proposed optimisation model and the solution approach. Furthermore, the results indicate that a decision maker can ascertain that the decisions derived from three cases considered have a 50% probability of being the most favourable outcomes.
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J Infus Nurs
March 2025
Author Affiliations: Takeda Development Center Americas, Inc., Cambridge, Massachusetts (Kim Duff); IQVIA Clinical Research Organization, Milan, Italy (Arianna Soresini); IQVIA Clinical Research Organization, Cambridge, Massachusetts (Nancy Wolf* and Alane Fairchild); IQVIA Clinical Research Organization, Ankara, Turkey (Şükran Altan**); IQVIA Clinical Research Organization, Mexico City, Mexico (Wendy Bencomo); University Clinical Center of Serbia, Belgrade, Serbia (Ivana Ivankovic); University Health Network, University of Toronto, Toronto, Ontario, Canada (Evelyn Sarpong); IQVIA Clinical Research Organization, Warsaw, Poland (Anna Kuczkowska).
Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% offers potential improvements in patient independence and tolerability versus intravenous immunoglobulin (IVIG) when used for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). fSCIG 10% also requires less frequent infusions and fewer infusion sites than conventional subcutaneous immunoglobulin (subcutaneous immunoglobulin without hyaluronidase). The ADVANCE-CIDP 1 study demonstrated fSCIG 10% efficacy and safety in preventing CIDP relapse and positive responses from patients in terms of satisfaction and treatment preference.
View Article and Find Full Text PDFJAMA Netw Open
March 2025
Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Importance: Cervical screening guidelines in the US recommend that most females can exit routine screening at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on the subsequent risks of cancer and cancer death in this subgroup of females are limited.
Objective: To estimate the risks of cervical cancer and cervical cancer death among females who meet the cotesting criteria to exit screening.
Am J Biol Anthropol
December 2024
Arizona State University, Tempe, Arizona, USA.
Biological anthropologists have long engaged in qualitative data analysis (QDA), though such work is not always foregrounded. In this article, we discuss the role of rigorous and systematic QDA in biological anthropology and consider how it can be understood and advanced. We first establish what kinds of qualitative data and analysis are used in biological anthropology.
View Article and Find Full Text PDFJ Opioid Manag
March 2025
Abt Global, LLC, Cambridge, Mas-sachusetts. ORCID: https://orcid.org/0000-0003-3391-2041.
Objective: The Six Building Blocks: A Team-Based Approach to Improving Opioid Management in Primary Care (6BBs) program provides a roadmap for improving the management of patients on opioid therapy for chronic pain. The goal of this project was to evaluate the How-to-Implement Toolkit (Toolkit) for clinics to independently implement the 6BBs without a practice facilitator.
Methods: Eight healthcare organizations with 62 clinics participated in the program.
Front Psychiatry
February 2025
Department of Neurological Rehabilitation, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China.
Introduction: Previous studies have found that depressive patients tend to have low levels of creatinine; however, the extent to which creatinine levels are associated with depression has been poorly investigated. Therefore, this study aimed to explore the relationship between creatinine levels and depression.
Methods: The participants and follow-up data from the China Health and Retirement Longitudinal Study (CHARLS), as well as metabolomics data from the Metabolite Network of Depression Database (MENDA), were collected.
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