The prevalence of obesity in Mexico has been rising dramatically from school age onward. The high consumption of ultra-processed food has been identified as a contributing factor. We explored the longitudinal association between household expenditure on ultra-processed foods and beverages (UPF) and changes in anthropometric indicators of obesity among Mexican children aged 5 to 10 years in 2002. We used data from the Mexican Family Life Survey (MxFLS), a longitudinal, probabilistic, multipurpose, and representative survey of the Mexican population conducted in 2002, which reports household expenditure on the main food and beverage groups, as well as anthropometric indicators and sociodemographic characteristics of household members, across three rounds surveyed between 2002 and 2012 (n = 2,677). The exposure variable was UPF expenditure, categorized into tertiles, and the outcomes studied were BMI z-score for age, waist circumference, and waist-to-height ratio. We estimated random effects models and generalized estimating equation models for longitudinal data. Using an interaction term between tertiles of UPF expenditure and survey rounds, we found that household membership in the middle and upper tertiles of UPF expenditure in 2002 was associated with an increase in waist circumference and waist-to-height ratio, particularly after three years of follow-up. For instance, the middle tertile of UPF expenditure was associated with an increase of 4.43 centimeters in waist circumference compared to the low tertile of UPF expenditure after three years of follow-up (p < 0.01). Our findings suggest that higher UPF expenditure in households with children aged 5-10 years drives abdominal obesity in the short and medium term, underscoring the need for comprehensive policies to limit the purchase and consumption of UPF from an early age.

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