[This corrects the article DOI: 10.1371/journal.pntd.0011642.].
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Efficacy and safety of mesenchymal stem cell therapies in retinitis pigmentosa: a systematic review and meta-analysis.
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Background: Retinitis pigmentosa (RP) is a retinal dystrophy and genetically heterogeneous group that causes vision loss and necessitates innovative therapeutic strategies, and mesenchymal stem cell (MSC) therapy has shown potential due to its regenerative and immunomodulatory properties. This meta-analysis aims to evaluate the efficacy and safety of MSC therapies in improving visual outcomes, focusing on the impact of various MSC types, administration methods, and duration of benefits.
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Circulating Blood-Based Proteins in Psychopathology and Cognition: A Mendelian Randomization Study.
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Importance: Peripheral (blood-based) biomarkers for psychiatric illness could benefit diagnosis and treatment, but research to date has typically been low throughput, and traditional case-control studies are subject to potential confounds of treatment and other exposures. Large-scale 2-sample mendelian randomization (MR) can examine the potentially causal impact of circulating proteins on neuropsychiatric phenotypes without these confounds.
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Background: Large language models (LLMs) are increasingly used in the medical field for diverse applications including differential diagnostic support. The estimated training data used to create LLMs such as the Generative Pretrained Transformer (GPT) predominantly consist of English-language texts, but LLMs could be used across the globe to support diagnostics if language barriers could be overcome. Initial pilot studies on the utility of LLMs for differential diagnosis in languages other than English have shown promise, but a large-scale assessment on the relative performance of these models in a variety of European and non-European languages on a comprehensive corpus of challenging rare-disease cases is lacking.
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