In Canada, the provision of Paediatric Palliative Care (PPC) services faces unique barriers due to a large geography and dispersed service population. This review identifies global challenges and strategies to inform efforts in strengthening Canadian PPC access and delivery. Utilizing a rapid review methodology, two databases were searched for publications between 2014 and 2024. Five hundred and ninety-five studies were imported, and 31 retained. Challenges identified in the literature included (i) uncertainty with team roles and responsibilities, (ii) lack of PPC familiarity, and (iii) navigating fragmented health systems. Recommendations included (i) enhancing education, (ii) streamlining access, and (iii) increasing awareness. Concerted effort between health leaders is essential to implement solutions towards a more integrated care system-one that considers the needs of all children. Prioritizing nationwide awareness, access, and capacity-building will ensure PPC meets the needs of all children and families, regardless of location.
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http://dx.doi.org/10.1177/08404704251322481 | DOI Listing |
Epileptic Disord
March 2025
Freiburg Epilepsy Center, Member of the ERN EpiCARE, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
A systematic review using PRISMA criteria was used to review the literature regarding the specific semiology of seizure arising (a) from the temporal pole or (b) from both medial and lateral temporal cortex. Evidence was analyzed with regard to information provided by intracranial EEG recordings and surgical outcomes, and an estimation of validity of reported signs and symptoms was performed. Semiology of seizures originating from the temporal pole was mostly related to diverse patterns of ictal spread rather than to the localization of seizure origin and comprised a wide variety of early signs and symptoms.
View Article and Find Full Text PDFMed Oncol
March 2025
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Cancer continues to be a significant global health concern, consistently ranking as one of the leading causes of mortality across diverse populations and socio-economic contexts. Genistein, a soy-derived isoflavonoid, has gained significant attention for its diverse health benefits, particularly its potent anticancer activity. Emerging pre-clinical and clinical evidences highlights its ability to modulate key cellular processes, including apoptosis, autophagy, angiogenesis, metastasis, immune responses and cell cycle regulation.
View Article and Find Full Text PDFOccup Ther Health Care
March 2025
Physiotherapy Research Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
This project aimed to explore the experiences of occupational therapists working in a specialist orthopedic hospital. Semi-structured interviews were carried out with eight occupational therapists working with total hip replacement patients, in an orthopedic hospital within the United Kingdom National Health Service (NHS) as part of a service review project. The data was recorded and transcribed and analyzed using the Reflexive Thematic Analysis.
View Article and Find Full Text PDFAging Dis
February 2025
Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
As the resident macrophages of the brain, microglia are crucial immune cells specific to the central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurodegenerative diseases (ND). As illnesses progress, microglia exhibit multiple phenotypes.
View Article and Find Full Text PDFMicrob Biotechnol
March 2025
Nova Institute for Health, Baltimore, Maryland, USA.
Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles in human cognition and behaviour. Included in this research is evidence indicating that gut microbes, through direct and indirect pathways, can influence aggression, anger, irritability and antisocial behaviour. Moreover, gut microbes can manufacture chemicals that are known to compromise cognition.
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