Umbilical diseases are associated with a decreased market value and increased mortality in calves, and laparotomy is often performed in the field. This retrospective study compared the effects of inhalation anesthesia (INH) and injection anesthesia (INJ) during the perioperative period. We analyzed the medical records of 57 Japanese black calves that underwent laparotomy for umbilical diseases (umbilical hernia and/or umbilical cord disease) between January 2017 and December 2023. The INH group (n = 38) received continuous isoflurane inhalation with pure oxygen as a carrier gas, while the INJ group (n = 19) received only injectable anesthesia (xylazine hydrochloride and pentobarbital sodium). We investigated sex, age at first examination, diagnosis, anesthetic method, anesthetic drugs and dosages, number of rescue doses, hospital stay duration, operation time, and prognosis. The number of rescue doses was defined as the number of times sedatives or analgesics (xylazine hydrochloride, pentobarbital sodium, and butorphanol tartrate) were injected during laparotomy. There were no differences in age at first examination (p = 0.8656) and hospital stay duration (p = 0.4646) between the groups. The INJ group required significantly more rescue doses (p < 0.0001) and had longer operation times (p = 0.0643) compared to the INH group. Postoperative prognosis was not significantly different between groups (p = 0.7026). Overall, INJ required multiple rescue doses, but the difference in the method of general anesthesia did not affect the hospital stay duration or prognosis.
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http://dx.doi.org/10.1007/s11259-025-10711-1 | DOI Listing |
Front Vet Sci
February 2025
Wildlife Institute of India, Dehradun, Uttarakhand, India.
The current study presents data on the immobilization and physiological responses of 26 distressed free-ranging snow leopards () in the trans-Himalayan regions of Ladakh, India, spanning three years from October 2020 to December 2023. Ketamine and xylazine were utilized in a drug mixture for rescue, rehabilitation, health assessment, and other capture purposes, with average doses of 6.535 ± 0.
View Article and Find Full Text PDFVet Res Commun
March 2025
Laboratory of Clinical Veterinary Medicine for Large Animals, Kitasato University School of Veterinary Medicine, 35-1 Higashi-23bancho, Towada, 034-8628, Aomori, Japan.
Umbilical diseases are associated with a decreased market value and increased mortality in calves, and laparotomy is often performed in the field. This retrospective study compared the effects of inhalation anesthesia (INH) and injection anesthesia (INJ) during the perioperative period. We analyzed the medical records of 57 Japanese black calves that underwent laparotomy for umbilical diseases (umbilical hernia and/or umbilical cord disease) between January 2017 and December 2023.
View Article and Find Full Text PDFIndian J Pediatr
March 2025
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.
Objectives: To compare the proportion of children with withdrawal syndrome in sedoanalgesic drug rotation protocol vs. sedoanalgesia with no rotation using Withdrawal Assessment Tool Version-1 (WAT-1).
Methods: Sixty children one mo to 18 y admitted to the Pediatric Intensive Care Unit (PICU) for mechanical ventilation were randomized into two groups in a 1:1 ratio.
Elife
March 2025
Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Background: In idiopathic pulmonary fibrosis (IPF) patients, alveolar architectures are lost and gas transfer function would decline, which cannot be rescued by conventional anti-fibrotic therapy. P63+ lung basal progenitor cells are reported to have potential to repair damaged lung epithelium in animal models, which need further investigation in clinical trials.
Methods: We cloned and expanded P63+ progenitor cells from IPF patients to manufacture cell product REGEND001, which were further characterized by morphology and single-cell transcriptomic analysis.
Chem Biol Drug Des
March 2025
Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
Forsythiaside A (FA) has anti-inflammatory and antioxidant properties. The aim of this study was to explore the antioxidant effects and mechanisms of FA in ischemic stroke (IS). In this work, IS-related genes were obtained through GEO, GeneCards, TTD, CTD, DrugBank, and MalaCards databases.
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