Background: Intramedullary spinal cord metastasis (ISCM) is rare and affects 0.9-2.1% of all cancer patients. Colorectal cancer accounts for about 3% of all ISCMs.
Methods: A systematic review of the literature in the most common electronic database (PubMed, Ovid MEDLINE and Ovid EMBASE) on cervical ISCM from colon cancer, according with "PRISMA statement" criteria, was done. In addition, we present a 76-year-old man with progressive paraparesis and negative anamnesis for primary tumors, who underwent surgical and complete resection of a C5-C6 intramedullary spinal cord colon metastasis.
Results: From a systematic review of the literature, only 8 previous cases of cervical ISCM from colon cancer were reported. The mean age at presentation was 68.3 years. Surgery was performed in 6 patients, including our case, whereas 1 patient was treated with radiotherapy and two patients were untreated. Survival time ranges from 2 weeks to 14 months (mean 3.8 months). The survival rates at 60 days and 120 days are 50% and 12.5%, respectively.
Conclusion: Cervical ISCM from colon cancer is rare and is usually detected at an advanced stage of primary tumor disease. The prognosis is poor and definitive recommendations cannot be made due to the lack of controlled comparative clinical studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10072-025-08084-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design, synthesis and biological evaluation of pyrazolo[3,4-]pyridine derivatives as dual CDK2/PIM1 inhibitors with potent anti-cancer activity and selectivity.
J Biomol Struct Dyn
March 2025
Applied Organic Chemistry Department, National Research Center, Dokki, Egypt.
The discovery of novel, selective inhibitors targeting CDK2 and PIM1 kinases, which regulate cell survival, proliferation, and treatment resistance, is crucial for advancing cancer therapy. This study reports the design, synthesis, and biological evaluation of three novel pyrazolo[3,4-]pyridine derivatives (), confirmed spectral analyses. These compounds were assessed for anti-cancer activity against breast, colon, liver, and cervical cancers using the MTT assay.
View Article and Find Full Text PDFEarly-Onset Colorectal Cancer: When to Include Cowden Syndrome in Your Differential Diagnosis.
ACG Case Rep J
March 2025
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Isoflavones: Promising Natural Agent for Cancer Prevention and Treatment.
Food Sci Nutr
March 2025
Department of Pharmacognosy, College of Pharmacy Jouf University Sakaka Saudi Arabia.
Isoflavones are currently being investigated by researchers in order to demonstrate their ability to prevent the proliferation of cancer cells. The current review aimed to demonstrate the potential of isoflavones to eliminate cancerous cells in the stomach, liver, lung, breast, and prostate, as their anticancer properties are due to the ability to block the signaling pathways of the extracellular signal-controlled kinase (MAPK/ERK) and proteasome (PI3K/AKT/mTOR). Isoflavones can inhibit the cell division of various cancer cells.
View Article and Find Full Text PDFHighly efficient isolation and multistep analysis of tumor cells from whole blood.
Lab Chip
March 2025
Robert Bosch GmbH, Corporate Sector Research and Advance Engineering, Robert-Bosch-Campus 1, 71272 Renningen, Germany.
We present a microfluidic solution for improved tumor cell analysis based on selection-free isolation of nucleated cells from whole blood. It consists of a high-density silicon microcavity array combined with the novel fluidic strategy of microfluidic decanting. This enables multistep on-chip staining protocols comprising sample loading-blocking-extracellular staining-fixation-permeabilization and intracellular staining to quantify tumor cells.
View Article and Find Full Text PDFBacteriocins from Lactic Acid Bacteria Could Modulate the Wnt Pathway: A Possible Therapeutic Candidate for the Management of Colorectal Cancer- An In silico Study.
Anticancer Agents Med Chem
March 2025
Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.
Introduction: Colorectal cancer (CRC) is a type of cancer that develops due to abnormal cell growth in the colon and rectum. Existing conventional CRC treatment strategies have side effects. Hence, exploring new and advanced techniques for bacterial CRC therapy is crucial.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!