Effect of Desmopressin in Post Kidney Biopsy Bleeding Complication in Patients with Reduced Renal Function: A Randomized Controlled Trial.

Background: Bleeding complications after kidney biopsy in patients with reduced renal function concern renal physician. We designed this study to examine the impact of desmopressin on reducing bleeding complications at 6 and 24 hours post-procedure in patients with eGFR≤60ml/min/1.73m2.

Methods: The patients with reduced renal function were randomized into an interventional group (n=74; intranasal desmopressin at 3mcg/kg) and a control group (n=78; intranasal saline as a placebo). The primary outcome measured was minor and major bleeding complications. The secondary outcome was the size of the hematoma at 6 hours with the risk of major complications.

Results: In interventional, 74 and 78 patients were in the control group. In minor complications, lumbar pain (p=1.0); gross hematuria (p=0.677) and hematoma at 6 hours (35.14% vs 46.15%, p-value=0.167) were similar. Hematoma at 24 hours was 18.92% in interventional group and 35.90% in control group (p-value=0.019). The size of hematoma at 6 hours (1.5cc vs. 2.7cc, p=0.342) and at 24 hours (1.25cc vs. 2.0, p=0.698) in the interventional and control groups, respectively. In major complications, blood transfusion (8.11% vs. 6.41%, p=0.686) and embolization procedure (2.70% vs. 1.28%, p=0.613} were similar between the two groups.

Conclusions: Both minor and major complications were similar between the two groups post-kidney biopsy. The size of the hematoma was also not different in the two groups.