The simultaneous introduction of two functional groups into molecules a one-pot process is of great importance for the synthesis of complex molecules. However, this remains a challenging task due to the need for precise control of regio- and chemo-selectivity. In this paper, we present a novel oxidative cross-dehydrogenation coupling (CDC) reaction that selectively introduces two nucleophiles at the C2,3-positions of indoles, thereby constructing the C-N and C-C bonds simultaneously in one pot. This method offers a streamlined and efficient approach for functionalizing indoles with high selectivity, expanding the synthetic toolbox for the construction of complex organic frameworks.
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