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Alluring Potential to Accelerate Emergence and Ameliorate Opioid-induced Respiratory Depression without Antagonizing Analgesia: Danavorexton Enters the Anesthetic Landscape.
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Department of Anesthesiology and Critical Care, Chronobiology and Sleep Institute, Center for Neuroscience of Unconsciousness and Reanimation Research Alliance, and Mahoney Institute of Neuroscience University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
A translational perspective of the malignant hematopoietic proteoglycome.
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COMT- Centre for Molecular and Translational Oncology, University of Parma, Parco Area delle Scienze, 11/A, Parma, 43124, Italy.
Proteoglycans are an ample family of complex extracellular matrix/cell surface components known to impact on virtually all biological processes that take place during life of a human being, in its healthy and diseased conditions. They are consolidated multivalent regulators of the behaviour of normal and malignant hematopoietic cells because of being critical components of their membranes, because of their pivotal role as multifaceted factors of the hematopoietic niches and because of acting as pillars of the tumour microenvironment. Likewise, they act as promoters of the growth, spreading and therapeutic resistance of diseased hematopoietic cells, also by modulating intracellular processes through a dual utilization of core protein domains and their glycosaminoglycan side chains.
View Article and Find Full Text PDFProgress in research on the formation mechanism, chemical composition, pharmacological effects, and clinical applications of Musk: A Review.
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State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China. Electronic address:
Ethnopharmacological Relevance: Moschus (Musk), a precious zoogenous medicinal material in traditional Chinese medicine (TCM), has been extensively utilized for centuries with well-documented therapeutic efficacy. It has important medicinal and economic value and is derived from the secretions of the scent gland sacs of male musk deer, which are dried and solidified under specific physiological conditions. Contemporary pharmacological investigations have validated its multifaceted pharmacological activities, including but not limited to anti-inflammatory, antioxidant, antitumor, and neuroregulatory effects, thereby substantiating its unique therapeutic status in the TCM pharmacopoeia.
View Article and Find Full Text PDFThe Safety of Social Media Instigated Visitation to National Parks in New South Wales, Australia: Insights From a Population Representative Sample.
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Issue Addressed: The integration of social media, smartphone technology and the widespread sharing of images has reshaped tourism, sparking new trends such as selfie-tourism and social media-driven travel. National parks, offering scenic and pristine landscapes, have become prime destinations for these pursuits. The popularity of platforms like Instagram and Facebook, combined with the influence of travel-focused social media personalities, has inspired a wave of visitors seeking "selfie-worthy" locations.
View Article and Find Full Text PDFThe was founded just over 20 years ago. As the organization grew, it incubated an impressive array of structures and processes to foster professional standards, training, credentialing, networking, and scholarship. A compelling and accelerating drumbeat of peer-reviewed publications has demonstrated the advancing base of evidence in which lifestyle medicine practice is rooted.
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