Doxy-PEP is used to prevent chlamydia, syphilis and gonorrhea infections in sexual and gender minority men and transgender women. We describe a systematic process for developing algorithms that allow for the identification of doxy-PEP prescriptions. Using an identified algorithm will allow for improved monitoring of implementation and effectiveness.
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http://dx.doi.org/10.1093/cid/ciaf109 | DOI Listing |
J Neural Eng
March 2025
Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI, United States of America.
Advances in electronics and materials science have led to the development of sophisticated components for clinical and research neurotechnology systems. However, instrumentation to easily evaluate how these components function in a complete system does not yet exist. In this work, we set out to design and validate a software-defined mixed-signal routing fabric, 'xDev', that enables neurotechnology system designers to rapidly iterate, evaluate, and deploy advanced multi-component systems.
View Article and Find Full Text PDFClin Infect Dis
March 2025
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States.
Doxy-PEP is used to prevent chlamydia, syphilis and gonorrhea infections in sexual and gender minority men and transgender women. We describe a systematic process for developing algorithms that allow for the identification of doxy-PEP prescriptions. Using an identified algorithm will allow for improved monitoring of implementation and effectiveness.
View Article and Find Full Text PDFBr J Clin Pharmacol
March 2025
Faculty of Health, Department of Medicine, Witten-Herdecke University, Witten, Germany.
Aims: This study aimed to evaluate the accuracy and completeness of GPT-4, a large language model, in answering clinical pharmacological questions related to pain therapy, with a focus on its potential as a tool for delivering patient-facing medical information. The objective was to assess its reliability in delivering medical information in the context of pain management.
Methods: A cross-sectional survey-based study was conducted with healthcare professionals, including physicians and pharmacists.
Hum Vaccin Immunother
December 2025
Department of Research & Development, Yither Biotech Co Ltd, Shanghai, China.
The World Health Organization (WHO) has recently declared another global health emergency due to the rapidly spreading monkeypox (Mpox) outbreak in numerous African countries. To address the unmet need to contain the outbreak using the existing vaccines, this study developed a lyophilization process for an effective, scalable and affordable Mpox mRNA-LNP vaccine candidate to address the global health crisis. A comprehensive evaluation and optimization of the vaccine formulation (the type/concentration of cryoprotectants, the type/concentration of buffer system, as well as the mRNA concentration and reconstitution solvent) and the freeze-drying process parameters (freezing method, temperature, cooling rate and primary/secondary drying conditions) were conducted.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
March 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Superficial temporal artery and middle cerebral artery (STA-MCA) bypass surgery is an effective method to enhance cerebral blood flow (CBF) in ischemic patients. However, the effectiveness of various bypass techniques varies with the diversity of Circle of Willis (CoW) structures. This study aims to develop a physiologically realistic hemodynamic model to optimize STA-MCA bypass planning for cerebral ischemia patients with different CoW structures.
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